TRDMT1 - tRNA (cytosine(38)-C(5))-methyltransferase - human protein (Function)
 
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TRDMT1 »  tRNA (cytosine(38)-C(5))-methyltransferase   [ EC 2.1.1.204 ]
 
Protein also known as:  DNA (cytosine-5)-methyltransferase-like protein 2 (Dnmt2).
Gene name:  TRDMT1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).  
1
  • CuratedUniProtKB
GO molecular function 
DNA (cytosine-5-)-methyltransferase activitydefinition[GO:0003886]  
1
  • TASPINC
DNA bindingdefinition[GO:0003677] silver  
  • IEAInterPro 2 GO
RNA bindingdefinition[GO:0003723]  
  • IEAUniProtKB KW
tRNA methyltransferase activitydefinition[GO:0008175]  
1
  • IDAMGI
GO biological process 
C-5 methylation of cytosinedefinition[GO:0090116]  
1
  • TASGOC
Response to amphetaminedefinition[GO:0001975] silver  
  • IEAOrtholog Compara
tRNA methylationdefinition[GO:0030488]  
1
  • IDAMGI
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.1.1.204: S-adenosyl-L-methionine + cytosine(38) in tRNA S-adenosyl-L-homocysteine + 5-methylcytosine(38) in tRNA.  
1
  • CuratedUniProtKB
Pathways 
 
More information is available from:
 

Keywords

Biological process 
tRNA processing  definition   [KW-0819]
Molecular function 
Methyltransferase  definition   [KW-0489]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TRDMT1
GenomeRNAi: 1787
PRO: PR:O14717