MAP2K7 - Dual specificity mitogen-activated protein kinase kinase 7 - human protein (Function)
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MAP2K7 »  Dual specificity mitogen-activated protein kinase kinase 7   [ EC ]  (MAPKK 7)
Protein also known as:  Stress-activated protein kinase kinase 4 (SAPKK4).
Gene name:  MAP2K7
Entry whose protein(s) existence is based on evidence at protein level
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Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
  • IEAOrtholog Compara
JUN kinase kinase activitydefinition[GO:0008545] silver  
  • IEAOrtholog Compara
Magnesium ion bindingdefinition[GO:0000287]  
  • IDAUniProtKB
MAP kinase kinase activitydefinition[GO:0004708]  
  • IDAUniProtKB
Mitogen-activated protein kinase kinase kinase bindingdefinition[GO:0031435] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
  • IPIIntAct
  • IPIUniProtKB
Protein C-terminus bindingdefinition[GO:0008022] silver  
  • IEAOrtholog Compara
Protein kinase bindingdefinition[GO:0019901]  
  • IPIUniProtKB
Protein phosphatase bindingdefinition[GO:0019903]  
  • ISSOrtholog Curator
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
Protein tyrosine kinase activitydefinition[GO:0004713]  
  • IEAUniProtKB KW
GO biological process 
Activation of JUN kinase activitydefinition[GO:0007257]  
  • ISSOrtholog Curator
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
Cellular response to sorbitoldefinition[GO:0072709] silver  
  • IEAOrtholog Compara
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
  • IEAUniProtKB KW
Positive regulation of neuron apoptotic processdefinition[GO:0043525] silver  
  • IEAOrtholog Compara
Response to stressdefinition[GO:0006950]  
  • IDAUniProtKB
Signal transductiondefinition[GO:0007165]  
Stress-activated MAPK cascadedefinition[GO:0051403]  
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
  • CuratedUniProtKB
It is regulated in the following manner
Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK.  
  • CuratedUniProtKB
More information is available from:
According to KEGG, this protein belongs to the following pathways:
ErbB signaling pathway  hsa04012+5609  
Fc epsilon RI signaling pathway  hsa04664+5609  
GnRH signaling pathway  hsa04912+5609  
Influenza A  hsa05164+5609  
MAPK signaling pathway  hsa04010+5609  
Neurotrophin signaling pathway  hsa04722+5609  
Osteoclast differentiation  hsa04380+5609  
Protein processing in endoplasmic reticulum  hsa04141+5609  
T cell receptor signaling pathway  hsa04660+5609  
Toll-like receptor signaling pathway  hsa04620+5609  
According to Reactome, this protein belongs to the following pathways:
FCERI mediated MAPK activation  REACT_163701  
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1  REACT_21368  
Oxidative Stress Induced Senescence  REACT_169436  


Biological process 
Apoptosis  definition   [KW-0053]
Stress response  definition   [KW-0346]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: MAP2K7
GenomeRNAi: 5609
PRO: PR:O14733