ACOT8 - Acyl-coenzyme A thioesterase 8 - human protein (Function)
 
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ACOT8 »  Acyl-coenzyme A thioesterase 8   [ EC 3.1.2.27 ]  (Acyl-CoA thioesterase 8)
 
Protein also known as:  Peroxisomal acyl-coenzyme A thioester hydrolase 1 (PTE-1).
Gene name:  ACOT8
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of peroxisome proliferation.  
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  • CuratedUniProtKB
GO molecular function 
Acyl-CoA hydrolase activitydefinition[GO:0047617]  
2
  • IDAUniProtKB
Choloyl-CoA hydrolase activitydefinition[GO:0033882]  
  • IEAEC 2 GO
Medium-chain acyl-CoA hydrolase activitydefinition[GO:0052815]  
1
  • IDAUniProtKB
Palmitoyl-CoA hydrolase activitydefinition[GO:0016290]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • IPIUniProtKB
GO biological process 
Acyl-CoA metabolic processdefinition[GO:0006637]  
1
  • IDAUniProtKB
Dicarboxylic acid catabolic processdefinition[GO:0043649]  
1
  • IDAUniProtKB
Peroxisome fissiondefinition[GO:0016559]  
1
  • IDAUniProtKB
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.2.27: Choloyl-CoA + H(2)O cholate + CoA.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Peroxisome  hsa04146+10005  
According to Reactome, this protein belongs to the following pathways:
alpha-linolenic acid (ALA) metabolism  REACT_121147  
Beta-oxidation of pristanoyl-CoA  REACT_17017  
Beta-oxidation of very long chain fatty acids  REACT_17062  
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol  REACT_11041  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Peroxisome biogenesis  definition   [KW-0962]
Molecular function 
Hydrolase  definition   [KW-0378]
Serine esterase  definition   [KW-0719]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACOT8
GenomeRNAi: 10005
PRO: PR:O14734