CDIPT - CDP-diacylglycerol--inositol 3-phosphatidyltransferase - human protein (Function)
 
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Protein
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CDIPT »  CDP-diacylglycerol--inositol 3-phosphatidyltransferase   [ EC 2.7.8.11 ]
 
Protein also known as:  Phosphatidylinositol synthase (PI synthase).
Gene name:  CDIPT
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme.  
1
  • CuratedUniProtKB
GO molecular function 
Alcohol bindingdefinition[GO:0043178] silver  
  • IEAOrtholog Compara
Carbohydrate bindingdefinition[GO:0030246] silver  
  • IEAOrtholog Compara
CDP-diacylglycerol-inositol 3-phosphatidyltransferase activitydefinition[GO:0003881]  
2
  • IDAUniProtKB
Diacylglycerol bindingdefinition[GO:0019992] silver  
  • IEAOrtholog Compara
Manganese ion bindingdefinition[GO:0030145] silver  
  • IEAOrtholog Compara
GO biological process 
CDP-diacylglycerol metabolic processdefinition[GO:0046341] silver  
  • IEAOrtholog Compara
Phosphatidylinositol biosynthetic processdefinition[GO:0006661]  
2
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.8.11: CDP-diacylglycerol + myo-inositol CMP + phosphatidyl-1D-myo-inositol.  
1
  • CuratedUniProtKB
It requires the following cofactor
Divalent metal cations; Mn(2+) or Mg(2+).  
1
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by PtdIns (product inhibition), phosphatidylinositol phosphate, and nucleoside di- and tri-phosphates.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Glycerophospholipid metabolism  hsa00564+10423  
Inositol phosphate metabolism  hsa00562+10423  
Metabolic pathways  hsa01100+10423  
Phosphatidylinositol signaling system  hsa04070+10423  
According to Reactome, this protein belongs to the following pathway:
Synthesis of PI  REACT_121000  
 
More information is available from:
 

Biophysicochemical properties

Dependence
pH Optimum pH is 9.0.
Temperature Optimum temperature is 50 degrees Celsius.

Keywords

Biological process 
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Phospholipid biosynthesis  definition   [KW-0594]
Phospholipid metabolism  definition   [KW-1208]
Molecular function 
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CDIPT
GenomeRNAi: 10423
PRO: PR:O14735