SLC9A3R1 - Na(+)/H(+) exchange regulatory cofactor NHE-RF1 - human protein (Function)
 
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SLC9A3R1 »  Na(+)/H(+) exchange regulatory cofactor NHE-RF1  (NHERF-1)
 
Protein also known as:  Solute carrier family 9 isoform A3 regulatory factor 1.
Gene name:  SLC9A3R1
Entry whose protein(s) existence is based on evidence at protein level
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1 169 2
GENE REF ISO

Function

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Overview 
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa.  
5
  • UniProtKB
According to TCDB this is a transporter from family:
the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family  8.A.24.1.1  
GO molecular function 
Beta-2 adrenergic receptor bindingdefinition[GO:0031698]  
1
  • UniProtKB
Beta-catenin bindingdefinition[GO:0008013]  
1
  • UniProtKB
Chloride channel regulator activitydefinition[GO:0017081]  
1
  • UniProtKB
Dopamine receptor bindingdefinition[GO:0050780] silver  
1
  • Ortholog Compara
Growth factor receptor bindingdefinition[GO:0070851]  
1
  • UniProtKB
PDZ domain bindingdefinition[GO:0030165]  
1
  • UniProtKB
Phosphatase bindingdefinition[GO:0019902]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
19
  • IntAct
  • UniProtKB
  • BHF-UCL
Protein complex bindingdefinition[GO:0032403] silver  
1
  • Ortholog Compara
Protein complex scaffolddefinition[GO:0032947] silver  
1
  • Ortholog Compara
Protein self-associationdefinition[GO:0043621]  
1
  • UniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • UniProtKB
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036] silver  
1
  • Ortholog Compara
Adenylate cyclase-activating dopamine receptor signaling pathwaydefinition[GO:0007191] silver  
1
  • Ortholog Compara
Bile acid secretiondefinition[GO:0032782]  
1
  • Ortholog Curator
Cellular phosphate ion homeostasisdefinition[GO:0030643] silver  
1
  • Ortholog Compara
Cellular protein localizationdefinition[GO:0034613] silver  
1
  • Ortholog Compara
Glutathione transportdefinition[GO:0034635]  
1
  • Ortholog Curator
Microvillus assemblydefinition[GO:0030033]  
1
  • UniProtKB
Negative regulation of cell migrationdefinition[GO:0030336] silver  
1
  • Ortholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285]  
2
  • UniProtKB
Negative regulation of ERK1 and ERK2 cascadedefinition[GO:0070373]  
1
  • UniProtKB
Negative regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014067]  
1
  • Ortholog Curator
Negative regulation of platelet-derived growth factor receptor signaling pathwaydefinition[GO:0010642]  
1
  • Ortholog Curator
Negative regulation of protein kinase B signalingdefinition[GO:0051898]  
1
  • UniProtKB
Negative regulation of sodium:proton antiporter activitydefinition[GO:0032416] silver  
1
  • Ortholog Compara
Phospholipase C-activating dopamine receptor signaling pathwaydefinition[GO:0060158] silver  
1
  • Ortholog Compara
Positive regulation of intrinsic apoptotic signaling pathwaydefinition[GO:2001244]  
1
  • UniProtKB
Protein complex assemblydefinition[GO:0006461]  
1
  • PINC
Regulation of excretiondefinition[GO:0044062] silver  
1
  • Ortholog Compara
Regulation of protein kinase activitydefinition[GO:0045859]  
1
  • Ortholog Curator
Regulation of sodium:proton antiporter activitydefinition[GO:0032415]  
1
  • UniProtKB
Renal absorptiondefinition[GO:0070293]  
1
  • Ortholog Curator
Renal phosphate ion absorptiondefinition[GO:0097291]  
1
  • UniProtKB
Renal sodium ion transportdefinition[GO:0003096] silver  
1
  • Ortholog Compara
Wnt signaling pathwaydefinition[GO:0016055]  
1
  • UniProtKB KW
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links