SLC9A3R1 - Na(+)/H(+) exchange regulatory cofactor NHE-RF1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
SLC9A3R1 »  Na(+)/H(+) exchange regulatory cofactor NHE-RF1  (NHERF-1)
 
Protein also known as:  Solute carrier family 9 isoform A3 regulatory factor 1.
Gene name:  SLC9A3R1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 153 1
GENE REF ISO

Function

 show evidences
Overview 
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa.  
4
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family  8.A.24.1.1  
GO molecular function 
Beta-2 adrenergic receptor bindingdefinition[GO:0031698]  
1
  • IPIUniProtKB
Beta-catenin bindingdefinition[GO:0008013]  
1
  • IPIUniProtKB
Chloride channel regulator activitydefinition[GO:0017081]  
1
  • IDAUniProtKB
Dopamine receptor bindingdefinition[GO:0050780] silver  
  • IEAOrtholog Compara
Growth factor receptor bindingdefinition[GO:0070851]  
1
  • IPIUniProtKB
PDZ domain bindingdefinition[GO:0030165]  
1
  • IPIUniProtKB
Phosphatase bindingdefinition[GO:0019902]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
19
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
Protein complex scaffolddefinition[GO:0032947] silver  
  • IEAOrtholog Compara
Protein self-associationdefinition[GO:0043621]  
1
  • IDAUniProtKB
Receptor bindingdefinition[GO:0005102]  
1
  • IPIUniProtKB
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036] silver  
  • IEAOrtholog Compara
Adenylate cyclase-activating dopamine receptor signaling pathwaydefinition[GO:0007191] silver  
  • IEAOrtholog Compara
Bile acid secretiondefinition[GO:0032782]  
  • ISSOrtholog Curator
Cellular phosphate ion homeostasisdefinition[GO:0030643] silver  
  • IEAOrtholog Compara
Cellular protein localizationdefinition[GO:0034613] silver  
  • IEAOrtholog Compara
Glutathione transportdefinition[GO:0034635]  
  • ISSOrtholog Curator
Microvillus assemblydefinition[GO:0030033]  
1
  • IMPUniProtKB
Negative regulation of cell migrationdefinition[GO:0030336] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285]  
2
  • IMPUniProtKB
Negative regulation of ERK1 and ERK2 cascadedefinition[GO:0070373]  
1
  • IDAUniProtKB
Negative regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014067]  
  • ISSOrtholog Curator
Negative regulation of platelet-derived growth factor receptor signaling pathwaydefinition[GO:0010642]  
  • ISSOrtholog Curator
Negative regulation of protein kinase B signalingdefinition[GO:0051898]  
1
  • IMPUniProtKB
Negative regulation of sodium ion transportdefinition[GO:0010766] silver  
  • IEAOrtholog Compara
Negative regulation of sodium:hydrogen antiporter activitydefinition[GO:0032416] silver  
  • IEAOrtholog Compara
Phospholipase C-activating dopamine receptor signaling pathwaydefinition[GO:0060158] silver  
  • IEAOrtholog Compara
Positive regulation of intrinsic apoptotic signaling pathwaydefinition[GO:2001244]  
1
  • IDAUniProtKB
Protein complex assemblydefinition[GO:0006461]  
1
  • TASPINC
Regulation of excretiondefinition[GO:0044062] silver  
  • IEAOrtholog Compara
Regulation of protein kinase activitydefinition[GO:0045859]  
  • ISSOrtholog Curator
Regulation of sodium:hydrogen antiporter activitydefinition[GO:0032415]  
1
  • NASUniProtKB
Renal absorptiondefinition[GO:0070293]  
  • ISSOrtholog Curator
Renal phosphate ion absorptiondefinition[GO:0097291]  
1
  • IMPUniProtKB
Renal sodium ion transportdefinition[GO:0003096] silver  
  • IEAOrtholog Compara
Wnt signaling pathwaydefinition[GO:0016055]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links