TERT - Telomerase reverse transcriptase - human protein (Function)
 
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Gene
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TERT »  Telomerase reverse transcriptase   [ EC 2.7.7.49 ]
 
Protein also known as:  Telomerase-associated protein 2 (TP2).
Gene name:  TERT
Entry whose protein(s) existence is based on evidence at protein level
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1 98 4
GENE REF ISO

Function

 show evidences
Overview 
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.  
13
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • BHF-UCL
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Nucleotidyltransferase activitydefinition[GO:0016779]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
7
  • IntAct
  • UniProtKB
  • BHF-UCL
  • HGNC
Protein homodimerization activitydefinition[GO:0042803]  
1
  • BHF-UCL
RNA bindingdefinition[GO:0003723]  
1
  • BHF-UCL
RNA-directed DNA polymerase activitydefinition[GO:0003964]  
1
  • BHF-UCL
Contributes to RNA-directed RNA polymerase activitydefinition[GO:0003968]  
1
  • BHF-UCL
Telomerase activitydefinition[GO:0003720]  
2
  • BHF-UCL
  • UniProtKB
Telomeric DNA bindingdefinition[GO:0042162]  
1
  • PINC
Telomeric RNA bindingdefinition[GO:0070034]  
2
  • BHF-UCL
Contributes to telomeric template RNA reverse transcriptase activitydefinition[GO:0003721]  
5
  • BHF-UCL
  • UniProtKB
Transcription coactivator bindingdefinition[GO:0001223]  
1
  • BHF-UCL
tRNA bindingdefinition[GO:0000049]  
1
  • BHF-UCL
GO biological process 
Cellular response to hypoxiadefinition[GO:0071456]  
1
  • BHF-UCL
DNA biosynthetic processdefinition[GO:0071897]  
2
  • BHF-UCL
DNA strand elongationdefinition[GO:0022616]  
1
  • BHF-UCL
Mitochondrion organizationdefinition[GO:0007005]  
1
  • BHF-UCL
Negative regulation of cellular senescencedefinition[GO:2000773]  
2
  • BHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001240]  
1
  • BHF-UCL
Negative regulation of gene expressiondefinition[GO:0010629]  
1
  • BHF-UCL
Negative regulation of production of siRNA involved in RNA interferencedefinition[GO:1903704]  
1
  • BHF-UCL
Positive regulation of nitric-oxide synthase activitydefinition[GO:0051000]  
1
  • BHF-UCL
Positive regulation of pri-miRNA transcription from RNA polymerase II promoterdefinition[GO:1902895]  
1
  • BHF-UCL
Positive regulation of Wnt signaling pathwaydefinition[GO:0030177]  
1
  • BHF-UCL
Production of siRNA involved in RNA interferencedefinition[GO:0030422]  
1
  • BHF-UCL
Replicative senescencedefinition[GO:0090399]  
1
  • BHF-UCL
RNA biosynthetic processdefinition[GO:0032774]  
1
  • BHF-UCL
RNA-dependent DNA replicationdefinition[GO:0006278]  
1
  • BHF-UCL
Telomere maintenancedefinition[GO:0000723]  
1
  • UniProtKB
Telomere maintenance via telomerasedefinition[GO:0007004]  
4
  • BHF-UCL
Transcription, RNA-templateddefinition[GO:0001172]  
1
  • BHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.7.49: Deoxynucleoside triphosphate + DNA(n) diphosphate + DNA(n+1).  
2
  • UniProtKB
  • PROSITE-ProRule
Pathways 
According to KEGG, this protein belongs to the following pathway:
HTLV-I infection  hsa05166+7015  
According to Reactome, this protein belongs to the following pathways:
formation of the beta-catenin:TCF transactivating complex  REACT_264242  
Telomere Extension By Telomerase  REACT_7974  
 

Keywords

Molecular function 
Nucleotidyltransferase  definition   [KW-0548]
RNA-directed DNA polymerase  definition   [KW-0695]
Ribonucleoprotein  definition   [KW-0687]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links