TERT - Telomerase reverse transcriptase - human protein (Function)
 
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TERT »  Telomerase reverse transcriptase   [ EC 2.7.7.49 ]
 
Protein also known as:  Telomerase-associated protein 2 (TP2).
Gene name:  TERT
Entry whose protein(s) existence is based on evidence at protein level
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1 87 4
GENE REF ISO

Function

 show evidences
Overview 
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.  
12
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
7
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
  • IPIHGNC
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDABHF-UCL
Telomerase activitydefinition[GO:0003720]  
2
  • IDABHF-UCL
  • IDAUniProtKB
Telomeric DNA bindingdefinition[GO:0042162]  
1
  • TASPINC
Telomeric RNA bindingdefinition[GO:0070034]  
1
  • IDABHF-UCL
Telomeric template RNA reverse transcriptase activitydefinition[GO:0003721]  
2
  • IDABHF-UCL
  • TASUniProtKB
GO biological process 
DNA strand elongationdefinition[GO:0022616]  
1
  • IDABHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001240]  
1
  • IMPBHF-UCL
Replicative senescencedefinition[GO:0090399]  
1
  • IMPBHF-UCL
Telomere formation via telomerasedefinition[GO:0032203]  
1
  • IDABHF-UCL
Telomere maintenancedefinition[GO:0000723]  
1
  • TASUniProtKB
Telomere maintenance via telomerasedefinition[GO:0007004]  
1
  • IMPBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.7.49: Deoxynucleoside triphosphate + DNA(n) diphosphate + DNA(n+1).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
HTLV-I infection  hsa05166+7015  
According to Reactome, this protein belongs to the following pathways:
formation of the beta-catenin:TCF transactivating complex  REACT_200753  
Telomere Extension By Telomerase  REACT_7974  
 

Keywords

Molecular function 
Nucleotidyltransferase  definition   [KW-0548]
RNA-directed DNA polymerase  definition   [KW-0695]
Ribonucleoprotein  definition   [KW-0687]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links