TERT - Telomerase reverse transcriptase - human protein (Sequence)
 
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Protein
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References

 
TERT »  Telomerase reverse transcriptase   [ EC 2.7.7.49 ]
 
Protein also known as:  Telomerase-associated protein 2 (TP2).
Gene name:  TERT
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Displayed isoform: Iso 1     

 
 
Isoform Iso 1   1132 aaMass: 126997 Da,  pI: 10.54
MPRAPRCRAV RSLLRSHYRE VLPLATFVRR LGPQGWRLVQ RGDPAAFRAL VAQCLVCVPW DARPPPAAPS FRQVSCLKEL VARVLQRLCE RGAKNVLAFG FALLDGARGG PPEAFTTSVR SYLPNTVTDA LRGSGAWGLL LRRVGDDVLV HLLARCALFV LVAPSCAYQV CGPPLYQLGA ATQARPPPHA SGPRRRLGCE RAWNHSVREA GVPLGLPAPG ARRRGGSASR SLPLPKRPRR GAAPEPERTP VGQGSWAHPG RTRGPSDRGF CVVSPARPAE EATSLEGALS GTRHSHPSVG RQHHAGPPST SRPPRPWDTP CPPVYAETKH FLYSSGDKEQ LRPSFLLSSL RPSLTGARRL VETIFLGSRP WMPGTPRRLP RLPQRYWQMR PLFLELLGNH AQCPYGVLLK THCPLRAAVT PAAGVCAREK PQGSVAAPEE EDTDPRRLVQ LLRQHSSPWQ VYGFVRACLR RLVPPGLWGS RHNERRFLRN TKKFISLGKH AKLSLQELTW KMSVRDCAWL RRSPGVGCVP AAEHRLREEI LAKFLHWLMS VYVVELLRSF FYVTETTFQK NRLFFYRKSV WSKLQSIGIR QHLKRVQLRE LSEAEVRQHR EARPALLTSR LRFIPKPDGL RPIVNMDYVV GARTFRREKR AERLTSRVKA LFSVLNYERA RRPGLLGASV LGLDDIHRAW RTFVLRVRAQ DPPPELYFVK VDVTGAYDTI PQDRLTEVIA SIIKPQNTYC VRRYAVVQKA AHGHVRKAFK SHVSTLTDLQ PYMRQFVAHL QETSPLRDAV VIEQSSSLNE ASSGLFDVFL RFMCHHAVRI RGKSYVQCQG IPQGSILSTL LCSLCYGDME NKLFAGIRRD GLLLRLVDDF LLVTPHLTHA KTFLRTLVRG VPEYGCVVNL RKTVVNFPVE DEALGGTAFV QMPAHGLFPW CGLLLDTRTL EVQSDYSSYA RTSIRASLTF NRGFKAGRNM RRKLFGVLRL KCHSLFLDLQ VNSLQTVCTN IYKILLLQAY RFHACVLQLP FHQQVWKNPT FFLRVISDTA SLCYSILKAK NAGMSLGAKG AAGPLPSEAV QWLCHQAFLL KLTRHRVTYV PLLGSLRTAQ TQLSRKLPGT TLTALEAAAN PALPSDFKTI LD

Sequence

 show evidences
Domain 
The primer grip sequence in the RT domain is required for telomerase activity and for stable association with short telomeric primers.  
1
  • CuratedUniProtKB
The RNA-interacting domain 1 (RD1)/N-terminal extension (NTE) is required for interaction with the pseudoknot-template domain of each of TERC dimers. It contains anchor sites that bind primer nucleotides upstream of the RNA-DNA hybrid and is thus an essential determinant of repeat addition processivity.  
1
  • CuratedUniProtKB
The RNA-interacting domain 2 (RD2) is essential for both interaction with the CR4-CR5 domain of TERC and for DNA synthesis.  
1
  • CuratedUniProtKB
PTM 
Phosphorylation at Tyr-707 under oxidative stress leads to translocation of TERT to the cytoplasm and reduces its antiapoptotic activity. Dephosphorylated by SHP2/PTPN11 leading to nuclear retention. Phosphorylation at Ser-227 by the AKT pathway promotes nuclear location. Phosphorylation at the G2/M phase at Ser-457 by DYRK2 promotes ubiquitination by the EDVP complex and degradation.  
6
  • CuratedUniProtKB
Ubiquitinated by the EDVP complex, a E3 ligase complex following phosphorylation at Ser-457 by DYRK2. Ubiquitinated leads to proteasomal degradation. In case of infection by HIV-1, the EDVP complex is hijacked by HIV-1 via interaction between HIV-1 Vpr and DCAF1/VPRBP, leading to ubiquitination and degradation.  
3
  • CuratedUniProtKB
 

Keywords

Coding sequence diversity 
Alternative splicing  definition   [KW-0025]
Polymorphism  definition   [KW-0621]
PTM 
Phosphoprotein  definition   [KW-0597]
Ubl conjugation  definition   [KW-0832]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
InterPro: IPR003545 [ Telomerase RT ]
InterPro: IPR000477 [ RVT ]
InterPro: IPR021891 [ Telomerase RBD ]
Pfam: PF00078 [ RVT 1 ]
Pfam: PF12009 [ Telomerase RBD ]
PRINTS: PR01365 [ TELOMERASERT ]
PROSITE: PS50878 [ RT POL ]
SMART: SM00975 [ Telomerase RBD ]
Genome annotation databases
Ensembl: Transcript: ENST00000310581;  Protein: ENSP00000309572;  Gene: ENSG00000164362.
Ensembl: Transcript: ENST00000296820;  Protein: ENSP00000296820;  Gene: ENSG00000164362.
Ensembl: Transcript: ENST00000460137;  Protein: ENSP00000425003;  Gene: ENSG00000164362.
Ensembl: Transcript: ENST00000334602;  Protein: ENSP00000334346;  Gene: ENSG00000164362.
Ensembl: Transcript: ENST00000508104;  Protein: ENSP00000426042;  Gene: ENSG00000164362.
KEGG: hsa:7015
UCSC: uc003jca.1
Organism-specific databases
MGI: MGI:1202709 [ Tert ]
Other
EvolutionaryTrace: O14746
PTM databases
PhosphoSite: O14746
Phylogenomic databases
eggNOG: NOG276584
HOGENOM: HOG000148780
HOVERGEN: HBG000460
InParanoid: O14746
KO: K11126
OMA: DTASCCY
OrthoDB: EOG744TB3
Sequence databases
CCDS: CCDS54831.1 [ O14746-3 ]
CCDS: CCDS3861.2 [ O14746-1 ]
EMBL: mRNA:  AF018167 . Translation:  AAC51724.1 .
EMBL: mRNA:  AB085628 . Translation:  BAC11010.1 .
EMBL: mRNA:  AB086950 . Translation:  BAC11015.1 .
EMBL: mRNA:  AF015950 . Translation:  AAC51672.1 .
EMBL: Genomic DNA:  AC114291 . No translation available.
EMBL: Genomic DNA:  AY007685 . Translation:  AAG23289.1 .
EMBL: mRNA:  AB086379 . Translation:  BAC11014.1 .
EMBL: Genomic DNA:  AF128893 , AF128894 . Translation:  AAD30037.1 .
EMBL: Genomic DNA:  CH471102 . Translation:  EAX08167.1 .
EMBL: Genomic DNA:  DQ264729 . Translation:  ABB72674.1 .
IPI: IPI00298218
IPI: IPI00168908
IPI: IPI00963895
IPI: IPI00384469
PIR: T03844
RefSeq: Protein:  NP_001180305.1. Nucleotide sequence:  NM_001193376.1.
RefSeq: Protein:  NP_937983.2. Nucleotide sequence:  NM_198253.2.
UniProtKB: O14746 [ TERT ]
Protocols and materials databases
DNASU: 7015