TNFRSF10B - Tumor necrosis factor receptor superfamily member 10B - human protein (Function)
 
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TNFRSF10B »  Tumor necrosis factor receptor superfamily member 10B
 
Protein also known as:  TNF-related apoptosis-inducing ligand receptor 2 (TRAIL-R2); CD antigen CD262.
Gene name:  TNFRSF10B
Entry whose protein(s) existence is based on evidence at protein level
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1 220 3
GENE REF ISO

Function

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Overview 
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.  
1
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
9
  • IPIIntAct
Receptor activitydefinition[GO:0004872]  
1
  • NASUniProtKB
TRAIL bindingdefinition[GO:0045569]  
1
  • NASUniProtKB
GO biological process 
Activation of NF-kappaB-inducing kinase activitydefinition[GO:0007250]  
2
  • NASUniProtKB
Apoptotic processdefinition[GO:0006915]  
1
  • NASUniProtKB
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Cellular response to mechanical stimulusdefinition[GO:0071260]  
1
  • IEPUniProtKB
Extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:0008625]  
1
  • NASUniProtKB
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressdefinition[GO:0070059]  
1
  • IMPUniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • IEPUniProtKB
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • NASUniProtKB
Response to endoplasmic reticulum stressdefinition[GO:0034976]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Apoptosis  hsa04210+8795  
Cytokine-cytokine receptor interaction  hsa04060+8795  
Influenza A  hsa05164+8795  
Measles  hsa05162+8795  
Natural killer cell mediated cytotoxicity  hsa04650+8795  
p53 signaling pathway  hsa04115+8795  
According to Reactome, this protein belongs to the following pathways:
Caspase-8 activation  REACT_1503  
Dimerization of procaspase-8  REACT_832  
Regulation by c-FLIP  REACT_164011  
TRAIL signaling  REACT_402  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TNFRSF10B
GenomeRNAi: 8795
PRO: PR:O14763
Chemistry
GuidetoPHARMACOLOGY: 1880