TPP1 - Tripeptidyl-peptidase 1 - human protein (Function)
 
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TPP1 »  Tripeptidyl-peptidase 1   [ EC 3.4.14.9 ]  (TPP-1)
 
Protein also known as:  Lysosomal pepstatin-insensitive protease (LPIC).
Gene name:  TPP1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 94 2
GENE REF ISO

Function

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Overview 
Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Endopeptidase activitydefinition[GO:0004175]  
2
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Peptidase activitydefinition[GO:0008233]  
1
  • IMPUniProtKB
Peptide bindingdefinition[GO:0042277]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Serine-type endopeptidase activitydefinition[GO:0004252] silver  
  • IEAInterPro 2 GO
Serine-type peptidase activitydefinition[GO:0008236]  
1
  • IMPUniProtKB
Tripeptidyl-peptidase activitydefinition[GO:0008240]  
5
  • IDAUniProtKB
GO biological process 
Bone resorptiondefinition[GO:0045453]  
1
  • IMPUniProtKB
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Epithelial cell differentiationdefinition[GO:0030855]  
1
  • IEPUniProtKB
Lipid metabolic processdefinition[GO:0006629]  
1
  • TASPINC
Lysosome organizationdefinition[GO:0007040]  
  • ISSOrtholog Curator
Nervous system developmentdefinition[GO:0007399]  
1
  • IMPUniProtKB
Neuromuscular process controlling balancedefinition[GO:0050885]  
  • ISSOrtholog Curator
Peptide catabolic processdefinition[GO:0043171]  
2
  • IMPUniProtKB
Protein catabolic processdefinition[GO:0030163]  
1
  • NASUniProtKB
Proteolysisdefinition[GO:0006508]  
2
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.14.9: Release of an N-terminal tripeptide from a polypeptide, but also has endopeptidase activity.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 calcium ion per subunit.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Lysosome  hsa04142+1200  
According to Reactome, this protein belongs to the following pathway:
XBP1(S) activates chaperone genes  REACT_18273  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: O14773
Other
GeneWiki: Tripeptidyl_peptidase_I
GenomeRNAi: 1200
PRO: PR:O14773