PHOX2A - Paired mesoderm homeobox protein 2A - human protein (Function)
 
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Protein
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References

 
PHOX2A »  Paired mesoderm homeobox protein 2A
 
Protein also known as:  Aristaless homeobox protein homolog.
Gene name:  PHOX2A
Family name: Paired homeobox
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.  
  • CuratedUniProtKB
GO molecular function 
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • IDABHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAInterPro 2 GO
GO biological process 
Dopaminergic neuron differentiationdefinition[GO:0071542]  
1
  • ICBHF-UCL
Locus ceruleus developmentdefinition[GO:0021703] silver  
  • IEAOrtholog Compara
Midbrain developmentdefinition[GO:0030901] silver  
  • IEAOrtholog Compara
Noradrenergic neuron differentiationdefinition[GO:0003357]  
2
  • ICBHF-UCL
Oculomotor nerve formationdefinition[GO:0021623] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IMPBHF-UCL
Regulation of respiratory gaseous exchangedefinition[GO:0043576] silver  
  • IEAOrtholog Compara
Somatic motor neuron differentiationdefinition[GO:0021523] silver  
  • IEAOrtholog Compara
Sympathetic nervous system developmentdefinition[GO:0048485] silver  
  • IEAOrtholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Trochlear nerve formationdefinition[GO:0021642] silver  
  • IEAOrtholog Compara
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PHOX2A
GenomeRNAi: 401
PRO: PR:O14813