PSMA7 - Proteasome subunit alpha type-7 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
PSMA7 »  Proteasome subunit alpha type-7   [ EC 3.4.25.1 ]
 
Protein also known as:  Proteasome subunit RC6-1.
Gene name:  PSMA7
Family name: Peptidase T1A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 46 3
GENE REF ISO

Function

 show evidences
Overview 
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.  
5
  • CuratedUniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
Protein bindingdefinition[GO:0005515]  
7
  • IPIIntAct
  • IPIUniProtKB
Threonine-type endopeptidase activitydefinition[GO:0004298]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.25.1: Cleavage of peptide bonds with very broad specificity.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Proteasome  hsa03050+5688  
According to Reactome, this protein belongs to the following pathways:
Apoptosis  REACT_578  
Cdc20:Phospho-APC/C mediated degradation of Cyclin A  REACT_6850  
Cell Cycle  REACT_115566  
Disease  REACT_116125  
DNA Replication  REACT_383  
Gene Expression  REACT_71  
Immune System  REACT_6900  
Metabolism  REACT_111217  
Metabolism of RNA  REACT_21257  
Mitotic M-M/G1 phases  REACT_21300  
Proteasome mediated degradation of PAK-2p34  REACT_13505  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Threonine protease  definition   [KW-0888]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PSMA7
GenomeRNAi: 5688
PRO: PR:O14818