FFAR1 - Free fatty acid receptor 1 - human protein (Function)
 
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FFAR1 »  Free fatty acid receptor 1
 
Protein also known as:  G-protein coupled receptor 40.
Gene name:  FFAR1
Entry whose protein(s) existence is based on evidence at transcript level
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1 33 1
GENE REF ISO

Function

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Overview 
Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G-proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway.  
1
  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
  • IEAUniProtKB KW
Lipid bindingdefinition[GO:0008289]  
  • IEAUniProtKB KW
GO biological process 
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
  • IEAUniProtKB KW
Glucose homeostasisdefinition[GO:0042593] silver  
  • IEAOrtholog Compara
Insulin secretiondefinition[GO:0030073] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion  REACT_19193  
Free fatty acid receptors  REACT_21268  
G alpha (q) signalling events  REACT_18283  
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)  REACT_24019  
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)  REACT_23824  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Free_fatty_acid_receptor_1
GenomeRNAi: 2864
PRO: PR:O14842
Chemistry
GuidetoPHARMACOLOGY: 225