FFAR3 - Free fatty acid receptor 3 - human protein (Function)
 
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FFAR3 »  Free fatty acid receptor 3
 
Protein also known as:  G-protein coupled receptor 41.
Gene name:  FFAR3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 19 1
GENE REF ISO

Function

 show evidences
Overview 
Receptor for short chain fatty acids. The activity of this receptor is coupled to the formation of inositol 1,4,5-trisphosphate, intracellular Ca2+ mobilization, the activation of ERK 1/2 and inhibition of intracellular cAMP accumulation. Coupled exclusively to the pertussis toxin-sensitive G(i/o)-alpha protein. The rank order of potency for agonists of this receptor is propionate = pentanoate = butyrate > acetate > formate.  
2
  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
3
  • IDAUniProtKB
Lipid bindingdefinition[GO:0008289]  
  • IEAUniProtKB KW
GO biological process 
Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwaydefinition[GO:0007193]  
1
  • IDAUniProtKB
Cellular response to fatty aciddefinition[GO:0071398]  
3
  • IDAUniProtKB
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
2
  • IDAUniProtKB
Mucosal immune responsedefinition[GO:0002385]  
  • ISSOrtholog Curator
Negative regulation of blood pressuredefinition[GO:0045776]  
  • ISSOrtholog Curator
Positive regulation of acute inflammatory response to non-antigenic stimulusdefinition[GO:0002879]  
  • ISSOrtholog Curator
Positive regulation of chemokine productiondefinition[GO:0032722]  
  • ISSOrtholog Curator
Positive regulation of cytokine production involved in immune responsedefinition[GO:0002720]  
  • ISSOrtholog Curator
Positive regulation of glucose import in response to insulin stimulusdefinition[GO:2001275]  
  • ISSOrtholog Curator
Regulation of hormone biosynthetic processdefinition[GO:0046885]  
  • ISSOrtholog Curator
Regulation of norepinephrine secretiondefinition[GO:0014061]  
  • ISSOrtholog Curator
Regulation of peptide hormone secretiondefinition[GO:0090276]  
  • ISSOrtholog Curator
Pathways 
According to Reactome, this protein belongs to the following pathways:
Free fatty acid receptors  REACT_21268  
G alpha (q) signalling events  REACT_18283  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Free_fatty_acid_receptor_3
GenomeRNAi: 2865
PRO: PR:O14843
Chemistry
GuidetoPHARMACOLOGY: 227