BCKDK - [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial - human protein (Function)
 
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BCKDK »  [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial   [ EC 2.7.11.4 ]
 
Protein also known as:  Branched-chain alpha-ketoacid dehydrogenase kinase (BCKDHKIN).
Gene name:  BCKDK
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 3
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex (By similarity).  
  • CuratedUniProtKB
GO molecular function 
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activitydefinition[GO:0047323]  
  • IEAEC 2 GO
ATP bindingdefinition[GO:0005524]  
  • ISSOrtholog Curator
Kinase activitydefinition[GO:0016301]  
1
  • TASHGNC
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • ISSOrtholog Curator
GO biological process 
Branched-chain amino acid catabolic processdefinition[GO:0009083]  
1
  • TASHGNC
  • ISSOrtholog Curator
Cellular amino acid catabolic processdefinition[GO:0009063]  
1
  • NASUniProtKB
Phosphorylationdefinition[GO:0016310]  
1
  • TASHGNC
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.4: ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BCKDK
GenomeRNAi: 10295
PRO: PR:O14874