IRF6 - Interferon regulatory factor 6 - human protein (Function)
 
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Protein
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IRF6 »  Interferon regulatory factor 6  (IRF-6)
 
Gene name:  IRF6
Family name: IRF
Entry whose protein(s) existence is based on evidence at protein level
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1 87 2
GENE REF ISO

Function

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Overview 
Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity).  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Regulatory region DNA bindingdefinition[GO:0000975] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
  • ISSOrtholog Curator
GO biological process 
Cell cycle arrestdefinition[GO:0007050]  
1
  • IDAUniProtKB
Cell developmentdefinition[GO:0048468] silver  
  • IEAOrtholog Compara
Keratinocyte differentiationdefinition[GO:0030216] silver  
  • IEAOrtholog Compara
Keratinocyte proliferationdefinition[GO:0043616] silver  
  • IEAOrtholog Compara
Mammary gland epithelial cell differentiationdefinition[GO:0060644]  
  • ISSOrtholog Curator
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IDAUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
  • ISSOrtholog Curator
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathways:
Interferon alpha/beta signaling  REACT_25162  
Interferon gamma signaling  REACT_25078  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: IRF6
GenomeRNAi: 3664
PRO: PR:O14896