CASK - Peripheral plasma membrane protein CASK - human protein (Function)
 
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CASK »  Peripheral plasma membrane protein CASK   [ EC 2.7.11.1 ]
 
Protein also known as:  Calcium/calmodulin-dependent serine protein kinase.
Gene name:  CASK
Family names: In the N-terminal section Protein kinase » CAMK Ser/Thr protein kinase » CaMK
MAGUK
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Guanylate kinase activitydefinition[GO:0004385]  
1
  • TASPINC
Neurexin family protein bindingdefinition[GO:0042043] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
GO biological process 
Calcium ion importdefinition[GO:0070509] silver  
  • IEAOrtholog Compara
Cell adhesiondefinition[GO:0007155]  
1
  • TASPINC
Negative regulation of cell-matrix adhesiondefinition[GO:0001953]  
1
  • IMPBHF-UCL
Negative regulation of cellular response to growth factor stimulusdefinition[GO:0090288]  
1
  • IMPBHF-UCL
Negative regulation of keratinocyte proliferationdefinition[GO:0010839]  
1
  • IMPBHF-UCL
Negative regulation of wound healingdefinition[GO:0061045]  
1
  • IMPBHF-UCL
Nucleotide phosphorylationdefinition[GO:0046939]  
1
  • TASGOC
Positive regulation of calcium ion importdefinition[GO:0090280] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Unlike other protein kinases, does not require a divalent cation such as magnesium for catalytic activity.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Differs from archetypal CaMK members in that the kinase domain exhibits a constitutively active conformation and the autoinhibitory region does not engage in direct contact with the ATP-binding cleft, although it still binds Ca(2+)/CAM.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Tight junction  hsa04530+8573  
According to Reactome, this protein belongs to the following pathways:
Cell-Cell communication  REACT_111155  
Extracellular matrix organization  REACT_118779  
 

Biophysicochemical properties

Kinetic parameters
Kinetics of autophosphorylation assay were measured, rather than phosphorylation of an exogenous substrate.
KM 563 uM for ATP

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CASK
GenomeRNAi: 8573
PRO: PR:O14936
Chemistry
GuidetoPHARMACOLOGY: 1959