AURKA - Aurora kinase A - human protein (Function)
 
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AURKA »  Aurora kinase A   [ EC 2.7.11.1 ]
 
Protein also known as:  Serine/threonine-protein kinase aurora-A.
Gene name:  AURKA
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.  
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  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Histone serine kinase activitydefinition[GO:0035174]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
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  • IntAct
  • UniProtKB
  • BHF-UCL
Protein kinase activitydefinition[GO:0004672]  
3
  • MGI
  • BHF-UCL
  • UniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • UniProtKB
Protein serine/threonine/tyrosine kinase activitydefinition[GO:0004712]  
1
  • UniProtKB
Ubiquitin protein ligase bindingdefinition[GO:0031625] silver  
1
  • Ortholog Compara
GO biological process 
Anterior/posterior axis specificationdefinition[GO:0009948] silver  
1
  • Ortholog Compara
Cell divisiondefinition[GO:0051301]  
1
  • UniProtKB KW
Centrosome localizationdefinition[GO:0051642] silver  
1
  • Ortholog Compara
Histone-serine phosphorylationdefinition[GO:0035404] silver  
1
  • Ortholog Compara
Mitotic centrosome separationdefinition[GO:0007100] silver  
1
  • Ortholog Compara
Mitotic nuclear divisiondefinition[GO:0007067]  
1
  • PINC
Mitotic spindle organizationdefinition[GO:0007052]  
1
  • RefGenome
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
1
  • Ortholog Compara
Negative regulation of protein bindingdefinition[GO:0032091]  
1
  • UniProtKB
Negative regulation of spindle checkpointdefinition[GO:0090233] silver  
1
  • Ortholog Compara
Neuron projection extensiondefinition[GO:1990138] silver  
1
  • Ortholog Compara
Positive regulation of mitosisdefinition[GO:0045840]  
1
  • UniProtKB
Positive regulation of oocyte maturationdefinition[GO:1900195] silver  
1
  • Ortholog Compara
Positive regulation of proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0032436] silver  
1
  • Ortholog Compara
Protein autophosphorylationdefinition[GO:0046777]  
1
  • UniProtKB
Protein localization to centrosomedefinition[GO:0071539] silver  
1
  • Ortholog Compara
Protein phosphorylationdefinition[GO:0006468]  
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  • UniProtKB
  • MGI
Regulation of centrosome cycledefinition[GO:0046605]  
1
  • UniProtKB
Regulation of cytokinesisdefinition[GO:0032465]  
1
  • RefGenome
Regulation of protein stabilitydefinition[GO:0031647]  
1
  • UniProtKB
Spindle assembly involved in female meiosis Idefinition[GO:0007057] silver  
1
  • Ortholog Compara
Spindle stabilizationdefinition[GO:0043146]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
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  • UniProtKB
It is regulated in the following manner
Activation of CDK1, appears to be an upstream event of AURKA activation. Phosphatase inhibitor-2 (PPP1R2) and TPX2 act also as activators. Inactivated by the G2 checkpoint. Inhibited by GADD45A and p53/TP53, and through dephosphorylation by protein phosphatase type 1 (PP1). MLN8054 is also a potent and selective inhibitor. Activated during the early phase of cilia disassembly in the presence of PIFO.  
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  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Oocyte meiosis  hsa04114+6790  
According to Reactome, this protein belongs to the following pathways:
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1  REACT_6761  
Regulation of PLK1 Activity at G2/M Transition  REACT_160315  
Note 
Centrosome amplification can occur when the cycles are uncoupled, and this amplification is associated with cancer and with an increase in the levels of chromosomal instability.  
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  • UniProtKB
Caution 
Authors initially considered AURKA/STK6 and STK15 as 2 different proteins (PubMed9771714). It is clear that they are the same protein.  
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  • UniProtKB
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Cilium biogenesis/degradation  definition   [KW-0970]
Mitosis  definition   [KW-0498]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Aurora_A_kinase
GenomeRNAi: 6790
PRO: PR:O14965
Chemistry
GuidetoPHARMACOLOGY: 1936