GAK - Cyclin-G-associated kinase - human protein (Function)
 
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Protein
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References

 
GAK »  Cyclin-G-associated kinase
 
Gene name:  GAK
Entry whose protein(s) existence is based on evidence at protein level
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1 51 2
GENE REF ISO

Function

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Overview 
Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
GO biological process 
Cell cycledefinition[GO:0007049]  
  • IEAUniProtKB KW
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Golgi Associated Vesicle Biogenesis  REACT_19400  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GAK_(protein)
GenomeRNAi: 2580
PRO: PR:O14976
Chemistry
GuidetoPHARMACOLOGY: 2027