ATP2A1 - Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 - human protein (Function)
 
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ATP2A1 »  Sarcoplasmic/endoplasmic reticulum calcium ATPase 1   [ EC 3.6.3.8 ]  (SERCA1)
 
Protein also known as:  Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform.
Gene name:  ATP2A1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 57 3
GENE REF ISO

Function

 show evidences
Overview 
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • ISSOrtholog Curator
  • IEAUniProtKB KW
Calcium ion bindingdefinition[GO:0005509]  
1
  • IMPUniProtKB
  • ISSOrtholog Curator
Calcium-transporting ATPase activitydefinition[GO:0005388]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIBHF-UCL
GO biological process 
Apoptotic mitochondrial changesdefinition[GO:0008637]  
1
  • IMPBHF-UCL
Isoform  SERCA1A   ATP catabolic processdefinition[GO:0006200]  
  • ISSOrtholog Curator
Calcium ion importdefinition[GO:0070509]  
1
  • IMPBHF-UCL
Isoform  SERCA1A   Calcium ion transmembrane transportdefinition[GO:0070588]  
1
  • IDAGOC
Calcium ion transportdefinition[GO:0006816]  
2
  • IDAUniProtKB
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressdefinition[GO:0070059]  
1
  • IMPBHF-UCL
Maintenance of mitochondrion locationdefinition[GO:0051659]  
1
  • IMPBHF-UCL
Negative regulation of endoplasmic reticulum calcium ion concentrationdefinition[GO:0032471]  
2
  • IMPBHF-UCL
Isoform  SERCA1A   Negative regulation of striated muscle contractiondefinition[GO:0045988]  
1
  • IMPUniProtKB
Positive regulation of endoplasmic reticulum calcium ion concentrationdefinition[GO:0032470]  
1
  • IMPBHF-UCL
Positive regulation of fast-twitch skeletal muscle fiber contractiondefinition[GO:0031448]  
1
  • IDAUniProtKB
Positive regulation of mitochondrial calcium ion concentrationdefinition[GO:0051561]  
1
  • IMPBHF-UCL
Isoform  SERCA1A   Regulation of striated muscle contractiondefinition[GO:0006942]  
1
  • IMPUniProtKB
Relaxation of skeletal muscledefinition[GO:0090076]  
1
  • IDABHF-UCL
Response to endoplasmic reticulum stressdefinition[GO:0034976]  
1
  • IMPBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.8: ATP + H(2)O + Ca(2+)(Side 1) ADP + phosphate + Ca(2+)(Side 2).  
  • CuratedUniProtKB
It is regulated in the following manner
Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+487  
Calcium signaling pathway  hsa04020+487  
Pancreatic secretion  hsa04972+487  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP2A1
GenomeRNAi: 487
PRO: PR:O14983