AREL1 - Apoptosis-resistant E3 ubiquitin protein ligase 1 - human protein (Function)
 
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Protein
Gene
References

 
AREL1 »  Apoptosis-resistant E3 ubiquitin protein ligase 1   [ EC 6.3.2.- ]
 
Gene name:  AREL1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation.  
1
  • CuratedUniProtKB
GO molecular function 
Ubiquitin-protein ligase activitydefinition[GO:0004842]  
1
  • IDAUniProtKB
  • IBARefGenome
GO biological process 
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IDAUniProtKB
Protein ubiquitination involved in ubiquitin-dependent protein catabolic processdefinition[GO:0042787]  
1
  • IDAUniProtKB
  • IBARefGenome
Pathways 
This protein is involved in the following pathway
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 9870