SEMA3E - Semaphorin-3E - human protein (Function)
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SEMA3E »  Semaphorin-3E
Gene name:  SEMA3E
Family name: Semaphorin
Entry whose protein(s) existence is based on evidence at protein level
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Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
  • IPIIntAct
Receptor activitydefinition[GO:0004872] silver  
  • IEAInterPro 2 GO
GO biological process 
Negative regulation of angiogenesisdefinition[GO:0016525]  
  • ISSOrtholog Curator
Negative regulation of cell-matrix adhesiondefinition[GO:0001953]  
  • ISSOrtholog Curator
Patterning of blood vesselsdefinition[GO:0001569]  
  • ISSOrtholog Curator
Regulation of actin cytoskeleton reorganizationdefinition[GO:2000249]  
  • ISSOrtholog Curator
Regulation of cell shapedefinition[GO:0008360]  
  • ISSOrtholog Curator
Semaphorin-plexin signaling pathwaydefinition[GO:0071526]  
  • ISSOrtholog Curator
Sprouting angiogenesisdefinition[GO:0002040]  
  • ISSOrtholog Curator
Synapse organizationdefinition[GO:0050808]  
  • ISSOrtholog Curator
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+9723  
According to Reactome, this protein belongs to the following pathway:
Other semaphorin interactions  REACT_19200  


Biological process 
Angiogenesis  definition   [KW-0037]
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GenomeRNAi: 9723
PRO: PR:O15041