SEMA3E - Semaphorin-3E - human protein (Function)
 
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SEMA3E »  Semaphorin-3E
 
Gene name:  SEMA3E
Family name: Semaphorin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity).  
1
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Receptor activitydefinition[GO:0004872] silver  
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  • InterPro 2 GO
Semaphorin receptor bindingdefinition[GO:0030215] silver  
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  • Ortholog Compara
GO biological process 
Negative regulation of angiogenesisdefinition[GO:0016525]  
1
  • Ortholog Curator
Negative regulation of cell-matrix adhesiondefinition[GO:0001953]  
1
  • Ortholog Curator
Patterning of blood vesselsdefinition[GO:0001569]  
1
  • Ortholog Curator
Regulation of actin cytoskeleton reorganizationdefinition[GO:2000249]  
1
  • Ortholog Curator
Regulation of cell shapedefinition[GO:0008360]  
1
  • Ortholog Curator
Semaphorin-plexin signaling pathwaydefinition[GO:0071526]  
1
  • Ortholog Curator
Sprouting angiogenesisdefinition[GO:0002040]  
1
  • Ortholog Curator
Synapse organizationdefinition[GO:0050808]  
1
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+9723  
According to Reactome, this protein belongs to the following pathway:
Other semaphorin interactions  REACT_19200  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 9723
PRO: PR:O15041