PER2 - Period circadian protein homolog 2 - human protein (Function)
 
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Protein
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References

 
PER2 »  Period circadian protein homolog 2
 
Protein also known as:  Circadian clock protein PERIOD 2.
Gene name:  PER2
Entry whose protein(s) existence is based on evidence at protein level
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1 26 2
GENE REF ISO

Function

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Overview 
Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Signal transducer activitydefinition[GO:0004871] silver  
  • IEAInterPro 2 GO
Transcription factor binding transcription factor activitydefinition[GO:0000989]  
  • ISSOrtholog Curator
GO biological process 
Circadian rhythmdefinition[GO:0007623] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
  • ISSOrtholog Curator
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Circadian rhythm - mammal  hsa04710+8864  
Herpes simplex infection  hsa05168+8864  
According to Reactome, this protein belongs to the following pathway:
Circadian Clock  REACT_24941  
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PER2
GenomeRNAi: 8864
PRO: PR:O15055