PER2 - Period circadian protein homolog 2 - human protein (Function)
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PER2 »  Period circadian protein homolog 2
Protein also known as:  Circadian clock protein PERIOD 2.
Gene name:  PER2
Entry whose protein(s) existence is based on evidence at protein level
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Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Signal transducer activitydefinition[GO:0004871] silver  
  • IEAInterPro 2 GO
Transcription coactivator activitydefinition[GO:0003713]  
  • ISSOrtholog Curator
Transcription factor binding transcription factor activitydefinition[GO:0000989]  
  • ISSOrtholog Curator
Transcription regulatory region sequence-specific DNA bindingdefinition[GO:0000976]  
  • ISSOrtholog Curator
GO biological process 
Circadian regulation of gene expressiondefinition[GO:0032922]  
  • ISSOrtholog Curator
Circadian regulation of translationdefinition[GO:0097167]  
  • ISSOrtholog Curator
Circadian rhythmdefinition[GO:0007623]  
Fatty acid metabolic processdefinition[GO:0006631]  
  • ISSOrtholog Curator
  • ISSOrtholog Curator
Glycogen biosynthetic processdefinition[GO:0005978]  
  • ISSOrtholog Curator
Histone H3 deacetylationdefinition[GO:0070932]  
  • ISSOrtholog Curator
Lactate biosynthetic processdefinition[GO:0019249]  
  • ISSOrtholog Curator
Negative regulation of circadian rhythmdefinition[GO:0042754]  
  • ISSOrtholog Curator
Negative regulation of fat cell proliferationdefinition[GO:0070345]  
  • ISSOrtholog Curator
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
  • ISSOrtholog Curator
Negative regulation of transcription regulatory region DNA bindingdefinition[GO:2000678]  
  • ISSOrtholog Curator
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
  • ISSOrtholog Curator
Regulation of cell cycledefinition[GO:0051726]  
  • ISSOrtholog Curator
Regulation of circadian rhythmdefinition[GO:0042752]  
  • ISSOrtholog Curator
Regulation of glutamate uptake involved in transmission of nerve impulsedefinition[GO:0051946]  
  • ISSOrtholog Curator
Regulation of insulin secretiondefinition[GO:0050796]  
  • ISSOrtholog Curator
Regulation of neurogenesisdefinition[GO:0050767]  
  • ISSOrtholog Curator
Regulation of vasoconstrictiondefinition[GO:0019229]  
  • ISSOrtholog Curator
Response to ischemiadefinition[GO:0002931]  
  • ISSOrtholog Curator
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
White fat cell differentiationdefinition[GO:0050872]  
  • ISSOrtholog Curator
According to KEGG, this protein belongs to the following pathways:
Circadian rhythm - mammal  hsa04710+8864  
Herpes simplex infection  hsa05168+8864  
According to Reactome, this protein belongs to the following pathway:
Circadian Clock  REACT_24941  


Biological process 
Biological rhythms  definition   [KW-0090]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: PER2
GenomeRNAi: 8864
PRO: PR:O15055