PFAS - Phosphoribosylformylglycinamidine synthase - human protein (Function)
 
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PFAS »  Phosphoribosylformylglycinamidine synthase   [ EC 6.3.5.3 ]  (FGAMS)
 
Protein also known as:  Formylglycinamide ribotide amidotransferase (FGARAT).
Gene name:  PFAS
Family name: In the N-terminal section FGAMS
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Phosphoribosylformylglycinamidine synthase activitydefinition[GO:0004642]  
1
  • IDAUniProtKB
GO biological process 
'de novo' IMP biosynthetic processdefinition[GO:0006189]  
1
  • NASUniProtKB
  • IEAUniPathway
Glutamine metabolic processdefinition[GO:0006541] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.3.5.3: ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H(2)O ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+5198  
Purine metabolism  hsa00230+5198  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Purine biosynthesis  definition   [KW-0658]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 5198
PRO: PR:O15067