ADAMTS3 - A disintegrin and metalloproteinase with thrombospondin motifs 3 - human protein (Function)
 
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ADAMTS3 »  A disintegrin and metalloproteinase with thrombospondin motifs 3   [ EC 3.4.24.- ]  (ADAMTS-3)
 
Protein also known as:  Procollagen II amino propeptide-processing enzyme.
Gene name:  ADAMTS3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 1
GENE REF ISO

Function

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Overview 
Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.  
  • CuratedUniProtKB
GO molecular function 
Heparin bindingdefinition[GO:0008201]  
  • IEAUniProtKB KW
Metalloendopeptidase activitydefinition[GO:0004222]  
1
  • NASUniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • NASUniProtKB
GO biological process 
Collagen biosynthetic processdefinition[GO:0032964]  
1
  • IDABHF-UCL
Collagen catabolic processdefinition[GO:0030574]  
1
  • NASUniProtKB
Collagen fibril organizationdefinition[GO:0030199]  
2
  • NASUniProtKB
  • ICBHF-UCL
Extracellular fibril organizationdefinition[GO:0043206]  
1
  • ICBHF-UCL
Protein processingdefinition[GO:0016485]  
1
  • IDABHF-UCL
Enzymatic activity 
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
Extracellular matrix organization  REACT_118779  
Metabolism of proteins  REACT_17015  
Caution 
Has sometimes been referred to as ADAMTS4.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADAMTS3
GenomeRNAi: 9508
PRO: PR:O15072