DCLK1 - Serine/threonine-protein kinase DCLK1 - human protein (Function)
 
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DCLK1 »  Serine/threonine-protein kinase DCLK1   [ EC 2.7.11.1 ]
 
Protein also known as:  Doublecortin domain-containing protein 3A.
Gene name:  DCLK1
Entry whose protein(s) existence is based on evidence at protein level
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1 48 4
GENE REF ISO

Function

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Overview 
Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein kinase activitydefinition[GO:0004672]  
1
  • TASPINC
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
Receptor signaling protein activitydefinition[GO:0005057]  
1
  • TASPINC
GO biological process 
Axon extensiondefinition[GO:0048675] silver  
  • IEAOrtholog Compara
Central nervous system developmentdefinition[GO:0007417]  
1
  • TASPINC
Central nervous system projection neuron axonogenesisdefinition[GO:0021952] silver  
  • IEAOrtholog Compara
Dendrite morphogenesisdefinition[GO:0048813] silver  
  • IEAOrtholog Compara
Endosomal transportdefinition[GO:0016197]  
1
  • NASUniProtKB
Forebrain developmentdefinition[GO:0030900] silver  
  • IEAOrtholog Compara
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Neuron migrationdefinition[GO:0001764] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • TASPINC
Response to virusdefinition[GO:0009615]  
1
  • IEPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: DCLK1
GenomeRNAi: 9201
PRO: PR:O15075
Chemistry
GuidetoPHARMACOLOGY: 2005