AGPAT2 - 1-acyl-sn-glycerol-3-phosphate acyltransferase beta - human protein (Function)
 
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Protein
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AGPAT2 »  1-acyl-sn-glycerol-3-phosphate acyltransferase beta
 
Gene name:  AGPAT2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.  
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  • CuratedUniProtKB
GO molecular function 
1-acylglycerol-3-phosphate O-acyltransferase activitydefinition[GO:0003841]  
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  • NASUniProtKB
  • IGIBHF-UCL
GO biological process 
CDP-diacylglycerol biosynthetic processdefinition[GO:0016024]  
  • IEAUniPathway
Epidermis developmentdefinition[GO:0008544] silver  
  • IEAOrtholog Compara
Phosphatidic acid biosynthetic processdefinition[GO:0006654]  
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  • IGIBHF-UCL
Phospholipid metabolic processdefinition[GO:0006644]  
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  • NASUniProtKB
Positive regulation of cytokine productiondefinition[GO:0001819]  
1
  • IMPBHF-UCL
Positive regulation of cytokine-mediated signaling pathwaydefinition[GO:0001961]  
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  • ICBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.51: Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate CoA + 1,2-diacyl-sn-glycerol 3-phosphate.  
3
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Fat digestion and absorption  hsa04975+10555  
Glycerolipid metabolism  hsa00561+10555  
Glycerophospholipid metabolism  hsa00564+10555  
Metabolic pathways  hsa01100+10555  
According to Reactome, this protein belongs to the following pathways:
Synthesis of PA  REACT_120906  
Triglyceride Biosynthesis  REACT_1190  
 
More information is available from:
 

Keywords

Biological process 
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Phospholipid biosynthesis  definition   [KW-0594]
Phospholipid metabolism  definition   [KW-1208]
Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AGPAT2
GenomeRNAi: 10555
PRO: PR:O15120