ANGPT2 - Angiopoietin-2 - human protein (Function)
 
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ANGPT2 »  Angiopoietin-2  (ANG-2)
 
Gene name:  ANGPT2
Entry whose protein(s) existence is based on evidence at protein level
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1 274 3
GENE REF ISO

Function

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Overview 
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.  
4
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Receptor bindingdefinition[GO:0005102]  
2
  • TASPINC
Receptor tyrosine kinase bindingdefinition[GO:0030971]  
1
  • IPIUniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525] silver  
  • IEAOrtholog Compara
Cellular response to growth factor stimulusdefinition[GO:0071363] silver  
  • IEAOrtholog Compara
Germ cell developmentdefinition[GO:0007281] silver  
  • IEAOrtholog Compara
Glomerulus vasculature developmentdefinition[GO:0072012]  
  • ISSOrtholog Curator
Maternal process involved in female pregnancydefinition[GO:0060135] silver  
  • IEAOrtholog Compara
Negative regulation of angiogenesisdefinition[GO:0016525] silver  
  • IEAOrtholog Compara
Negative regulation of blood vessel endothelial cell migrationdefinition[GO:0043537]  
1
  • IDAUniProtKB
Negative regulation of cell-substrate adhesiondefinition[GO:0010812] silver  
  • IEAOrtholog Compara
Negative regulation of positive chemotaxisdefinition[GO:0050928]  
1
  • IDAUniProtKB
Organ regenerationdefinition[GO:0031100] silver  
  • IEAOrtholog Compara
Positive regulation of angiogenesisdefinition[GO:0045766] silver  
  • IEAOrtholog Compara
Response to activitydefinition[GO:0014823] silver  
  • IEAOrtholog Compara
Response to glucosedefinition[GO:0009749] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to mechanical stimulusdefinition[GO:0009612] silver  
  • IEAOrtholog Compara
Response to organic cyclic compounddefinition[GO:0014070] silver  
  • IEAOrtholog Compara
Response to radiationdefinition[GO:0009314] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Tie signaling pathwaydefinition[GO:0048014]  
1
  • IDAUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Tie2 Signaling  REACT_12621  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Differentiation  definition   [KW-0221]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ANGPT2
GenomeRNAi: 285
PRO: PR:O15123