MDM4 - Protein Mdm4 - human protein (Function)
 
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MDM4 »  Protein Mdm4
 
Protein also known as:  Mdm2-like p53-binding protein.
Gene name:  MDM4
Family name: MDM2/MDM4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 138 5
GENE REF ISO

Function

 show evidences
Overview 
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.  
2
  • CuratedUniProtKB
GO molecular function 
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
18
  • IPIIntAct
  • IPIUniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • TASUniProtKB
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • IEPUniProtKB
Cellular response to hypoxiadefinition[GO:0071456]  
1
  • IEPUniProtKB
DNA damage response, signal transduction by p53 class mediatordefinition[GO:0030330]  
1
  • IEPUniProtKB
G0 to G1 transitiondefinition[GO:0045023]  
1
  • IEPUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAInterPro 2 GO
Negative regulation of cell cycle arrestdefinition[GO:0071157] silver  
  • IEAInterPro 2 GO
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • TASPINC
Negative regulation of protein catabolic processdefinition[GO:0042177]  
1
  • IMPUniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDAUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Protein complex assemblydefinition[GO:0006461]  
1
  • IDAUniProtKB
Protein stabilizationdefinition[GO:0050821]  
1
  • IEPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
p53 signaling pathway  hsa04115+4194  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MDM4
GenomeRNAi: 4194
PRO: PR:O15151