POLR1C - DNA-directed RNA polymerases I and III subunit RPAC1 - human protein (Function)
 
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POLR1C »  DNA-directed RNA polymerases I and III subunit RPAC1  (RNA polymerases I and III subunit AC1)
 
Protein also known as:  DNA-directed RNA polymerases I and III 40 kDa polypeptide (RPA40).
Gene name:  POLR1C
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 28 2
GENE REF ISO

Function

 show evidences
Overview 
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
  • IEAInterPro 2 GO
DNA-directed RNA polymerase activitydefinition[GO:0003899]  
1
  • TASPINC
Protein dimerization activitydefinition[GO:0046983] silver  
  • IEAInterPro 2 GO
Contributes to RNA polymerase I activitydefinition[GO:0001054] silver  
  • IBARefGenome
Contributes to RNA polymerase III activitydefinition[GO:0001056] silver  
  • IBARefGenome
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytosolic DNA-sensing pathway  hsa04623+9533  
Metabolic pathways  hsa01100+9533  
Purine metabolism  hsa00230+9533  
Pyrimidine metabolism  hsa00240+9533  
RNA polymerase  hsa03020+9533  
According to Reactome, this protein belongs to the following pathways:
NoRC negatively regulates rRNA expression  REACT_200856  
RNA Polymerase I Chain Elongation  REACT_2204  
RNA Polymerase I Promoter Escape  REACT_1913  
RNA Polymerase I Transcription Initiation  REACT_953  
RNA Polymerase I Transcription Termination  REACT_1074  
RNA Polymerase III Abortive And Retractive Initiation  REACT_22339  
RNA Polymerase III Chain Elongation  REACT_756  
RNA Polymerase III Transcription Initiation From Type 1 Promoter  REACT_347  
RNA Polymerase III Transcription Initiation From Type 2 Promoter  REACT_1036  
RNA Polymerase III Transcription Initiation From Type 3 Promoter  REACT_571  
RNA Polymerase III Transcription Termination  REACT_63  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: POLR1C
GenomeRNAi: 9533
PRO: PR:O15160