POLR1C - DNA-directed RNA polymerases I and III subunit RPAC1 - human protein (Function)
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POLR1C »  DNA-directed RNA polymerases I and III subunit RPAC1  (RNA polymerases I and III subunit AC1)
Protein also known as:  DNA-directed RNA polymerases I and III 40 kDa polypeptide (RPA40).
Gene name:  POLR1C
Entry whose protein(s) existence is based on evidence at protein level
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1 29 2


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DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
  • IEAInterPro 2 GO
DNA-directed RNA polymerase activitydefinition[GO:0003899]  
Protein dimerization activitydefinition[GO:0046983] silver  
  • IEAInterPro 2 GO
Contributes to RNA polymerase I activitydefinition[GO:0001054] silver  
  • IBARefGenome
Contributes to RNA polymerase III activitydefinition[GO:0001056] silver  
  • IBARefGenome
According to KEGG, this protein belongs to the following pathways:
Cytosolic DNA-sensing pathway  hsa04623+9533  
Metabolic pathways  hsa01100+9533  
Purine metabolism  hsa00230+9533  
Pyrimidine metabolism  hsa00240+9533  
RNA polymerase  hsa03020+9533  
According to Reactome, this protein belongs to the following pathways:
Gene Expression  REACT_71  
Immune System  REACT_6900  
Transcription  REACT_1788  


Biological process 
Transcription  definition   [KW-0804]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: POLR1C
GenomeRNAi: 9533
PRO: PR:O15160