POLR1C - DNA-directed RNA polymerases I and III subunit RPAC1 - human protein (Function)
 
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POLR1C »  DNA-directed RNA polymerases I and III subunit RPAC1  (RNA polymerases I and III subunit AC1)
 
Protein also known as:  DNA-directed RNA polymerases I and III 40 kDa polypeptide (RPA40).
Gene name:  POLR1C
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).  
3
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
1
  • InterPro 2 GO
DNA-directed RNA polymerase activitydefinition[GO:0003899]  
1
  • PINC
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
Protein dimerization activitydefinition[GO:0046983] silver  
1
  • InterPro 2 GO
Contributes to RNA polymerase I activitydefinition[GO:0001054]  
1
  • RefGenome
Contributes to RNA polymerase III activitydefinition[GO:0001056]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytosolic DNA-sensing pathway  hsa04623+9533  
Metabolic pathways  hsa01100+9533  
Purine metabolism  hsa00230+9533  
Pyrimidine metabolism  hsa00240+9533  
RNA polymerase  hsa03020+9533  
According to Reactome, this protein belongs to the following pathways:
Cytosolic sensors of pathogen-associated DNA  R-HSA-1834949  
NoRC negatively regulates rRNA expression  R-HSA-427413  
RNA Polymerase I Chain Elongation  R-HSA-73777  
RNA Polymerase I Promoter Escape  R-HSA-73772  
RNA Polymerase I Transcription Initiation  R-HSA-73762  
RNA Polymerase I Transcription Termination  R-HSA-73863  
RNA Polymerase III Abortive And Retractive Initiation  R-HSA-749476  
RNA Polymerase III Chain Elongation  R-HSA-73780  
RNA Polymerase III Transcription Initiation From Type 1 Promoter  R-HSA-76061  
RNA Polymerase III Transcription Initiation From Type 2 Promoter  R-HSA-76066  
RNA Polymerase III Transcription Initiation From Type 3 Promoter  R-HSA-76071  
RNA Polymerase III Transcription Termination  R-HSA-73980  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: POLR1C
GenomeRNAi: 9533
PRO: PR:O15160