T - Brachyury protein - human protein (Function)
 
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T »  Brachyury protein
 
Protein also known as:  Protein T.
Gene name:  T
Entry whose protein(s) existence is based on evidence at transcript level
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1 43 2
GENE REF ISO

Function

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Overview 
Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.  
  • CuratedUniProtKB
GO molecular function 
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
1
  • IPIBHF-UCL
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
  • ISSOrtholog Curator
RNA polymerase II distal enhancer sequence-specific DNA bindingdefinition[GO:0000980]  
1
  • IDABHF-UCL
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705]  
1
  • IDABHF-UCL
RNA polymerase II transcription factor bindingdefinition[GO:0001085]  
  • ISSOrtholog Curator
RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcriptiondefinition[GO:0001191]  
  • ISSOrtholog Curator
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • NASPINC
GO biological process 
Anterior/posterior axis specification, embryodefinition[GO:0008595]  
1
  • TASPINC
BMP signaling pathwaydefinition[GO:0030509] silver  
  • IEAOrtholog Compara
Bone morphogenesisdefinition[GO:0060349] silver  
  • IEAOrtholog Compara
Canonical Wnt signaling pathwaydefinition[GO:0060070] silver  
  • IEAOrtholog Compara
Determination of heart left/right asymmetrydefinition[GO:0061371] silver  
  • IEAOrtholog Compara
Embryonic skeletal system developmentdefinition[GO:0048706] silver  
  • IEAOrtholog Compara
Heart morphogenesisdefinition[GO:0003007]  
1
  • IDABHF-UCL
Mesoderm developmentdefinition[GO:0007498]  
1
  • TASPINC
Mesoderm migration involved in gastrulationdefinition[GO:0007509] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
  • ISSOrtholog Curator
Neural plate morphogenesisdefinition[GO:0001839] silver  
  • IEAOrtholog Compara
Neural tube closuredefinition[GO:0001843] silver  
  • IEAOrtholog Compara
Notochord formationdefinition[GO:0014028] silver  
  • IEAOrtholog Compara
Penetration of zona pellucidadefinition[GO:0007341] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiationdefinition[GO:0003257]  
1
  • IDABHF-UCL
Post-anal tail morphogenesisdefinition[GO:0036342] silver  
  • IEAOrtholog Compara
Primitive streak formationdefinition[GO:0090009]  
1
  • NASBHF-UCL
Signal transductiondefinition[GO:0007165]  
1
  • NASPINC
Signal transduction involved in regulation of gene expressiondefinition[GO:0023019] silver  
  • IEAOrtholog Compara
SMAD protein signal transductiondefinition[GO:0060395] silver  
  • IEAOrtholog Compara
Somitogenesisdefinition[GO:0001756] silver  
  • IEAOrtholog Compara
Vasculogenesisdefinition[GO:0001570] silver  
  • IEAOrtholog Compara
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Brachyury
GenomeRNAi: 6862
PRO: PR:O15178