EPHB6 - Ephrin type-B receptor 6 - human protein (Function)
 
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Protein
Gene
References

 
EPHB6 »  Ephrin type-B receptor 6
 
Protein also known as:  Tyrosine-protein kinase-defective receptor EPH-6.
Gene name:  EPHB6
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 52 3
GENE REF ISO

Function

 show evidences
Overview 
Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.  
3
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Ephrin receptor activitydefinition[GO:0005003] silver  
1
  • InterPro 2 GO
Isoform  Iso 2   Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Receptor activitydefinition[GO:0004872]  
1
  • PINC
GO biological process 
Protein phosphorylationdefinition[GO:0006468] silver  
1
  • InterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+2051  
According to Reactome, this protein belongs to the following pathways:
EPH-ephrin mediated repulsion of cells  REACT_264198  
EPH-Ephrin signaling  REACT_264068  
EPHB-mediated forward signaling  REACT_263952  
Ephrin signaling  REACT_264047  
 

Keywords

Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: EPHB6
GenomeRNAi: 2051
PRO: PR:O15197
Chemistry
GuidetoPHARMACOLOGY: 1834