CLIC2 - Chloride intracellular channel protein 2 - human protein (Function)
 
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CLIC2 »  Chloride intracellular channel protein 2
 
Protein also known as:  XAP121.
Gene name:  CLIC2
Family name: Chloride channel CLIC
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx.  
3
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the intracellular chloride channel (clic) family  1.A.12.1.5  
GO molecular function 
Chloride channel activitydefinition[GO:0005254]  
1
  • TASPINC
Glutathione peroxidase activitydefinition[GO:0004602]  
1
  • IDABHF-UCL
Not  Glutathione transferase activitydefinition[GO:0004364]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
Voltage-gated chloride channel activitydefinition[GO:0005247] silver  
  • IEAInterPro 2 GO
GO biological process 
Chloride transmembrane transportdefinition[GO:1902476]  
1
  • TASGOC
Ion transmembrane transportdefinition[GO:0034220]  
1
  • TASGOC
Metabolic processdefinition[GO:0008152]  
1
  • IDAGOC
Negative regulation of ryanodine-sensitive calcium-release channel activitydefinition[GO:0060315]  
2
  • IDABHF-UCL
Oxidation-reduction processdefinition[GO:0055114]  
1
  • IDAGOC
Positive regulation of bindingdefinition[GO:0051099]  
1
  • IDABHF-UCL
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium iondefinition[GO:0010881]  
1
  • ICBHF-UCL
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumdefinition[GO:0010880]  
2
  • IDABHF-UCL
Signal transductiondefinition[GO:0007165]  
1
  • TASUniProtKB
Transmembrane transportdefinition[GO:0055085]  
1
  • TASGOC
Transportdefinition[GO:0006810]  
1
  • TASPINC
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Chloride channel  definition   [KW-0869]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CLIC2
GenomeRNAi: 1193
PRO: PR:O15247