ACOX3 - Peroxisomal acyl-coenzyme A oxidase 3 - human protein (Function)
 
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Protein
Gene
References

 
ACOX3 »  Peroxisomal acyl-coenzyme A oxidase 3   [ EC 1.3.3.6 ]
 
Protein also known as:  Branched-chain acyl-CoA oxidase (BRCACox).
Gene name:  ACOX3
Family name: Acyl-CoA oxidase
Entry whose protein(s) existence is based on evidence at protein level
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1 22 2
GENE REF ISO

Function

 show evidences
Overview 
Oxidizes the CoA-esters of 2-methyl-branched fatty acids (By similarity).  
1
  • CuratedUniProtKB
GO molecular function 
Acyl-CoA dehydrogenase activitydefinition[GO:0003995] silver  
  • IEAInterPro 2 GO
Flavin adenine dinucleotide bindingdefinition[GO:0050660] silver  
  • IEAInterPro 2 GO
Receptor bindingdefinition[GO:0005102]  
1
  • IPIUniProtKB
GO biological process 
Fatty acid beta-oxidation using acyl-CoA oxidasedefinition[GO:0033540]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.3.3.6: Acyl-CoA + O(2) trans-2,3-dehydroacyl-CoA + H(2)O(2).  
  • CuratedUniProtKB
It requires the following cofactor
FAD (By similarity).  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
alpha-Linolenic acid metabolism  hsa00592+8310  
Biosynthesis of unsaturated fatty acids  hsa01040+8310  
Fatty acid metabolism  hsa00071+8310  
Metabolic pathways  hsa01100+8310  
Peroxisome  hsa04146+8310  
PPAR signaling pathway  hsa03320+8310  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACOX3
GenomeRNAi: 8310
PRO: PR:O15254