MAPK13 - Mitogen-activated protein kinase 13 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
MAPK13 »  Mitogen-activated protein kinase 13   [ EC 2.7.11.24 ]  (MAPK 13)
 
Protein also known as:  Mitogen-activated protein kinase p38 delta (MAP kinase p38 delta).
Gene name:  MAPK13
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 56 1
GENE REF ISO

Function

 show evidences
Overview 
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.  
8
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
MAP kinase activitydefinition[GO:0004707]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
2
  • IDABHF-UCL
  • IDAMGI
GO biological process 
Cell cycledefinition[GO:0007049]  
  • IEAUniProtKB KW
Intracellular signal transductiondefinition[GO:0035556]  
1
  • IDAUniProtKB
MAPK cascadedefinition[GO:0000165]  
2
  • IDAGOC
Peptidyl-serine phosphorylationdefinition[GO:0018105]  
1
  • IDABHF-UCL
Positive regulation of inflammatory responsedefinition[GO:0050729]  
1
  • ICBHF-UCL
Positive regulation of interleukin-6 productiondefinition[GO:0032755]  
1
  • IMPBHF-UCL
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • IEAUniProtKB KW
Response to osmotic stressdefinition[GO:0006970]  
1
  • IDAUniProtKB
Response to stressdefinition[GO:0006950]  
1
  • IDAUniProtKB
Signal transduction by phosphorylationdefinition[GO:0023014]  
2
  • IDAGOC
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.24: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by phosphorylation on threonine and tyrosine by dual specificity kinases, MAP2K3/MKK3, MAP2K6/MKK6, MAP2K4/MKK4 and MAP2K7/MKK7. Activation by ultraviolet radiation, hyperosmotic shock, anisomycin or by TNF-alpha is mediated by MAP2K3/MKK3. Inhibited by dual specificity phosphatase DUSP1.  
3
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Amyotrophic lateral sclerosis (ALS)  hsa05014+5603  
Chagas disease (American trypanosomiasis)  hsa05142+5603  
Dopaminergic synapse  hsa04728+5603  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+5603  
Fc epsilon RI signaling pathway  hsa04664+5603  
GnRH signaling pathway  hsa04912+5603  
Hepatitis C  hsa05160+5603  
Influenza A  hsa05164+5603  
Leishmaniasis  hsa05140+5603  
Leukocyte transendothelial migration  hsa04670+5603  
MAPK signaling pathway  hsa04010+5603  
Neurotrophin signaling pathway  hsa04722+5603  
NOD-like receptor signaling pathway  hsa04621+5603  
Osteoclast differentiation  hsa04380+5603  
Pertussis  hsa05133+5603  
Progesterone-mediated oocyte maturation  hsa04914+5603  
RIG-I-like receptor signaling pathway  hsa04622+5603  
Salmonella infection  hsa05132+5603  
Shigellosis  hsa05131+5603  
T cell receptor signaling pathway  hsa04660+5603  
Toll-like receptor signaling pathway  hsa04620+5603  
Toxoplasmosis  hsa05145+5603  
Tuberculosis  hsa05152+5603  
VEGF signaling pathway  hsa04370+5603  
According to Reactome, this protein belongs to the following pathways:
Cell-Cell communication  REACT_111155  
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Stress response  definition   [KW-0346]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MAPK13
GenomeRNAi: 5603
PRO: PR:O15264
Chemistry
GuidetoPHARMACOLOGY: 1502