ATXN7 - Ataxin-7 - human protein (Function)
 
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Protein
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References

 
ATXN7 »  Ataxin-7
 
Protein also known as:  Spinocerebellar ataxia type 7 protein.
Gene name:  ATXN7
Family name: Ataxin-7
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization.  
2
  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
  • UniProtKB
GO biological process 
Histone deubiquitinationdefinition[GO:0016578]  
1
  • UniProtKB
Microtubule cytoskeleton organizationdefinition[GO:0000226]  
1
  • UniProtKB
Negative regulation of insulin-like growth factor receptor signaling pathwaydefinition[GO:0043569] silver  
1
  • Ortholog Compara
Negative regulation of phosphorylationdefinition[GO:0042326] silver  
1
  • Ortholog Compara
Nucleus organizationdefinition[GO:0006997]  
1
  • PINC
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Visual perceptiondefinition[GO:0007601]  
1
  • PINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
HATs acetylate histones  REACT_172610  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 6314
PRO: PR:O15265