TCAP - Telethonin - human protein (Function)
 
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TCAP »  Telethonin
 
Protein also known as:  Titin cap protein.
Gene name:  TCAP
Entry whose protein(s) existence is based on evidence at protein level
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1 38 1
GENE REF ISO

Function

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Overview 
Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.  
  • CuratedUniProtKB
GO molecular function 
FATZ bindingdefinition[GO:0051373]  
1
  • IPIBHF-UCL
Ion channel bindingdefinition[GO:0044325]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
  • IPIUniProtKB
Protein binding, bridgingdefinition[GO:0030674]  
1
  • IDABHF-UCL
Structural constituent of muscledefinition[GO:0008307]  
1
  • IMPBHF-UCL
Titin bindingdefinition[GO:0031432]  
3
  • IPIBHF-UCL
Titin Z domain bindingdefinition[GO:0070080]  
1
  • IPIBHF-UCL
GO biological process 
Adult heart developmentdefinition[GO:0007512]  
1
  • IMPBHF-UCL
Cardiac muscle contractiondefinition[GO:0060048]  
2
  • IMPBHF-UCL
Cardiac muscle fiber developmentdefinition[GO:0048739]  
1
  • IMPBHF-UCL
Cardiac muscle hypertrophydefinition[GO:0003300]  
1
  • IMPBHF-UCL
Cardiac muscle hypertrophy in response to stressdefinition[GO:0014898]  
1
  • IMPBHF-UCL
Cardiac muscle tissue morphogenesisdefinition[GO:0055008]  
1
  • IMPBHF-UCL
Cardiac myofibril assemblydefinition[GO:0055003]  
1
  • IMPBHF-UCL
Detection of mechanical stimulusdefinition[GO:0050982]  
1
  • TASBHF-UCL
Detection of muscle stretchdefinition[GO:0035995]  
1
  • IMPBHF-UCL
Otic vesicle formationdefinition[GO:0030916] silver  
  • IEAOrtholog Compara
Protein complex assemblydefinition[GO:0006461]  
1
  • TASPINC
Response to muscle stretchdefinition[GO:0035994]  
1
  • TASBHF-UCL
Sarcomere organizationdefinition[GO:0045214]  
2
  • TASBHF-UCL
Sarcomerogenesisdefinition[GO:0048769]  
1
  • IMPBHF-UCL
Skeletal muscle contractiondefinition[GO:0003009]  
1
  • IEPBHF-UCL
Skeletal muscle myosin thick filament assemblydefinition[GO:0030241]  
1
  • IMPBHF-UCL
Skeletal muscle thin filament assemblydefinition[GO:0030240]  
1
  • IMPBHF-UCL
Somitogenesisdefinition[GO:0001756] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Muscle contraction  REACT_17044  
Note 
The C-terminal domain appears to be unstructured in solution. It may promote the assembly of higher-order TTN complexes.  
  • CuratedUniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Telethonin
GenomeRNAi: 8557
PRO: PR:O15273