TP73 - Tumor protein p73 - human protein (Function)
 
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TP73 »  Tumor protein p73
 
Protein also known as:  p53-like transcription factor.
Gene name:  TP73
Family name: P53
Entry whose protein(s) existence is based on evidence at protein level
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1 384 10
GENE REF ISO

Function

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Overview 
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.  
3
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IBARefGenome
Damaged DNA bindingdefinition[GO:0003684] silver  
  • IBARefGenome
Double-stranded DNA bindingdefinition[GO:0003690] silver  
  • IBARefGenome
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
P53 bindingdefinition[GO:0002039] silver  
  • IBARefGenome
Protein bindingdefinition[GO:0005515]  
12
  • IPIIntAct
  • IPIUniProtKB
Protein kinase bindingdefinition[GO:0019901]  
2
  • IPIUniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IDAMGI
Isoform  Beta   Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIUniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDAUniProtKB
GO biological process 
Activation of MAPK activitydefinition[GO:0000187] silver  
  • IEAOrtholog Compara
Cell cycle arrestdefinition[GO:0007050] silver  
  • IEAOrtholog Compara
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • IDAUniProtKB
Cellular response to UVdefinition[GO:0034644] silver  
  • IBARefGenome
Cerebrospinal fluid secretiondefinition[GO:0033326] silver  
  • IEAOrtholog Compara
Digestive tract morphogenesisdefinition[GO:0048546] silver  
  • IEAOrtholog Compara
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatordefinition[GO:0006978] silver  
  • IBARefGenome
Hippocampus developmentdefinition[GO:0021766] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAOrtholog Compara
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630]  
1
  • TASPINC
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatordefinition[GO:0042771]  
2
  • IDAUniProtKB
  • IBARefGenome
Kidney developmentdefinition[GO:0001822] silver  
  • IEAOrtholog Compara
Mismatch repairdefinition[GO:0006298]  
1
  • TASPINC
Mitotic G1 DNA damage checkpointdefinition[GO:0031571] silver  
  • IBARefGenome
Negative regulation of JUN kinase activitydefinition[GO:0043508] silver  
  • IBARefGenome
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IBARefGenome
Negative regulation of neuron differentiationdefinition[GO:0045665] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IBARefGenome
Neuron developmentdefinition[GO:0048666] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
  • IEAOrtholog Compara
Positive regulation of cell sizedefinition[GO:0045793] silver  
  • IEAOrtholog Compara
Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatordefinition[GO:1902167] silver  
  • IEAOrtholog Compara
Positive regulation of oligodendrocyte differentiationdefinition[GO:0048714] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IDAUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • IDAUniProtKB
  • IDAMGI
Post-embryonic developmentdefinition[GO:0009791] silver  
  • IEAOrtholog Compara
Protein tetramerizationdefinition[GO:0051262] silver  
  • IEAInterPro 2 GO
Release of cytochrome c from mitochondriadefinition[GO:0001836] silver  
  • IEAOrtholog Compara
Response to gamma radiationdefinition[GO:0010332] silver  
  • IBARefGenome
Response to organonitrogen compounddefinition[GO:0010243] silver  
  • IEAOrtholog Compara
Response to X-raydefinition[GO:0010165] silver  
  • IBARefGenome
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Enzymatic activity 
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Measles  hsa05162+7161  
Neurotrophin signaling pathway  hsa04722+7161  
p53 signaling pathway  hsa04115+7161  
Note 
Activated and stabilized by interaction with RANBP9.  
  • CuratedUniProtKB
Maps to a chromosome region frequently mutated in diverse cell lines of human cancer. Appears not to be frequently mutated in human cancers, in contrast to p53/TP53. Hemizygosity is observed in neuroblastoma and oligodendroglioma.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Cell cycle  definition   [KW-0131]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: P73
GenomeRNAi: 7161
PRO: PR:O15350