TP73 - Tumor protein p73 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
TP73 »  Tumor protein p73
 
Protein also known as:  p53-like transcription factor.
Gene name:  TP73
Family name: P53
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 422 12
GENE REF ISO

Function

 show evidences
Overview 
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.  
4
  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682]  
1
  • RefGenome
Damaged DNA bindingdefinition[GO:0003684]  
1
  • RefGenome
Double-stranded DNA bindingdefinition[GO:0003690]  
1
  • RefGenome
Identical protein bindingdefinition[GO:0042802]  
1
  • IntAct
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
P53 bindingdefinition[GO:0002039]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
14
  • IntAct
  • UniProtKB
Protein kinase bindingdefinition[GO:0019901]  
2
  • UniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • NTNU_SB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
1
  • NTNU_SB
Sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0000981]  
1
  • UniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • MGI
Isoform  Beta   Transcription factor bindingdefinition[GO:0008134]  
1
  • UniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • UniProtKB
GO biological process 
Activation of MAPK activitydefinition[GO:0000187] silver  
1
  • Ortholog Compara
Cell cycle arrestdefinition[GO:0007050] silver  
1
  • Ortholog Compara
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • UniProtKB
Cellular response to UVdefinition[GO:0034644]  
1
  • RefGenome
Cerebrospinal fluid secretiondefinition[GO:0033326] silver  
1
  • Ortholog Compara
Digestive tract morphogenesisdefinition[GO:0048546] silver  
1
  • Ortholog Compara
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatordefinition[GO:0006978]  
1
  • RefGenome
Hippocampus developmentdefinition[GO:0021766] silver  
1
  • Ortholog Compara
Inflammatory responsedefinition[GO:0006954] silver  
1
  • Ortholog Compara
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630]  
1
  • PINC
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatordefinition[GO:0042771]  
3
  • UniProtKB
  • RefGenome
Kidney developmentdefinition[GO:0001822] silver  
1
  • Ortholog Compara
Mismatch repairdefinition[GO:0006298]  
1
  • PINC
Mitotic G1 DNA damage checkpointdefinition[GO:0031571]  
1
  • RefGenome
Negative regulation of cardiac muscle cell proliferationdefinition[GO:0060044]  
1
  • MGI
Negative regulation of JUN kinase activitydefinition[GO:0043508]  
1
  • RefGenome
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
1
  • RefGenome
Negative regulation of neuron differentiationdefinition[GO:0045665] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • RefGenome
Neuron developmentdefinition[GO:0048666] silver  
1
  • Ortholog Compara
Positive regulation of cell sizedefinition[GO:0045793] silver  
1
  • Ortholog Compara
Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatordefinition[GO:1902167] silver  
1
  • Ortholog Compara
Positive regulation of oligodendrocyte differentiationdefinition[GO:0048714] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
4
  • UniProtKB
  • NTNU_SB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • UniProtKB
  • MGI
Post-embryonic developmentdefinition[GO:0009791] silver  
1
  • Ortholog Compara
Protein tetramerizationdefinition[GO:0051262] silver  
1
  • InterPro 2 GO
Regulation of gene expressiondefinition[GO:0010468]  
1
  • MGI
Regulation of mitotic cell cycledefinition[GO:0007346]  
1
  • MGI
Release of cytochrome c from mitochondriadefinition[GO:0001836] silver  
1
  • Ortholog Compara
Response to gamma radiationdefinition[GO:0010332]  
1
  • RefGenome
Response to organonitrogen compounddefinition[GO:0010243] silver  
1
  • Ortholog Compara
Response to X-raydefinition[GO:0010165]  
1
  • RefGenome
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • GOC
Enzymatic activity 
It requires the following cofactor
 Zn(2+) : Binds 1 zinc ion per subunit.  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Measles  hsa05162+7161  
Neurotrophin signaling pathway  hsa04722+7161  
p53 signaling pathway  hsa04115+7161  
Note 
Activated and stabilized by interaction with RANBP9.  
1
  • UniProtKB
Maps to a chromosome region frequently mutated in diverse cell lines of human cancer. Appears not to be frequently mutated in human cancers, in contrast to p53/TP53. Hemizygosity is observed in neuroblastoma and oligodendroglioma.  
1
  • UniProtKB
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Cell cycle  definition   [KW-0131]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: P73
GenomeRNAi: 7161
PRO: PR:O15350