GPR37 - Prosaposin receptor GPR37 - human protein (Function)
 
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Protein
Gene
References

 
GPR37 »  Prosaposin receptor GPR37
 
Protein also known as:  Parkin-associated endothelin receptor-like receptor (PAELR).
Gene name:  GPR37
Entry whose protein(s) existence is based on evidence at protein level
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1 39 1
GENE REF ISO

Function

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Overview 
Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.  
4
  • UniProtKB
GO molecular function 
G-protein coupled peptide receptor activitydefinition[GO:0008528]  
1
  • ParkinsonsUK-UCL
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • PINC
Heat shock protein bindingdefinition[GO:0031072]  
1
  • ParkinsonsUK-UCL
Hsp70 protein bindingdefinition[GO:0030544]  
1
  • ParkinsonsUK-UCL
Peptide bindingdefinition[GO:0042277]  
1
  • ParkinsonsUK-UCL
Protein bindingdefinition[GO:0005515]  
1
  • ParkinsonsUK-UCL
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
2
  • ParkinsonsUK-UCL
GO biological process 
Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwaydefinition[GO:0007193]  
1
  • ParkinsonsUK-UCL
Dopamine biosynthetic processdefinition[GO:0042416] silver  
1
  • Ortholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • PINC
Locomotion involved in locomotory behaviordefinition[GO:0031987] silver  
1
  • Ortholog Compara
Negative regulation of hydrogen peroxide-induced cell deathdefinition[GO:1903206]  
1
  • ParkinsonsUK-UCL
Positive regulation of dopamine metabolic processdefinition[GO:0045964] silver  
1
  • Ortholog Compara
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • ParkinsonsUK-UCL
Pathways 
According to KEGG, this protein belongs to the following pathway:
Parkinson's disease  hsa05012+2861  
According to Reactome, this protein belongs to the following pathway:
Peptide ligand-binding receptors  REACT_14819  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GPR37
GenomeRNAi: 2861
PRO: PR:O15354
Chemistry
GuidetoPHARMACOLOGY: 103