GRIN2D - Glutamate receptor ionotropic, NMDA 2D - human protein (Function)
 
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GRIN2D »  Glutamate receptor ionotropic, NMDA 2D  (GluN2D)
 
Protein also known as:  Glutamate [NMDA] receptor subunit epsilon-4.
Gene name:  GRIN2D
Entry whose protein(s) existence is based on evidence at protein level
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1 27 1
GENE REF ISO

Function

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Overview 
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.  
  • CuratedUniProtKB
GO molecular function 
Extracellular-glutamate-gated ion channel activitydefinition[GO:0005234] silver  
  • IBARefGenome
N-methyl-D-aspartate selective glutamate receptor activitydefinition[GO:0004972] silver  
  • IBARefGenome
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Adult locomotory behaviordefinition[GO:0008344] silver  
  • IEAOrtholog Compara
Ion transmembrane transportdefinition[GO:0034220] silver  
  • IBARefGenome
Ionotropic glutamate receptor signaling pathwaydefinition[GO:0035235] silver  
  • IBARefGenome
Regulation of sensory perception of paindefinition[GO:0051930] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • NASPINC
Startle responsedefinition[GO:0001964] silver  
  • IEAOrtholog Compara
Synaptic transmission, glutamatergicdefinition[GO:0035249] silver  
  • IBARefGenome
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+2906  
Amyotrophic lateral sclerosis (ALS)  hsa05014+2906  
Calcium signaling pathway  hsa04020+2906  
Glutamatergic synapse  hsa04724+2906  
Long-term potentiation  hsa04720+2906  
Neuroactive ligand-receptor interaction  hsa04080+2906  
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GRIN2D
GenomeRNAi: 2906
PRO: PR:O15399
Chemistry
GuidetoPHARMACOLOGY: 459