FOXP2 - Forkhead box protein P2 - human protein (Function)
 
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Protein
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FOXP2 »  Forkhead box protein P2
 
Protein also known as:  Trinucleotide repeat-containing gene 10 protein.
Gene name:  FOXP2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.  
1
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
2
  • UniProtKB
  • IntAct
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • BHF-UCL
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700]  
1
  • BHF-UCL
GO biological process 
Caudate nucleus developmentdefinition[GO:0021757]  
1
  • UniProtKB
Cerebral cortex developmentdefinition[GO:0021987]  
1
  • BHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • BHF-UCL
Putamen developmentdefinition[GO:0021758]  
1
  • UniProtKB
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FOXP2
GenomeRNAi: 93986
PRO: PR:O15409