FOXP2 - Forkhead box protein P2 - human protein (Function)
 
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Protein
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References

 
FOXP2 »  Forkhead box protein P2
 
Protein also known as:  Trinucleotide repeat-containing gene 10 protein.
Gene name:  FOXP2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.  
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IBARefGenome
DNA bindingdefinition[GO:0003677]  
1
  • IDAUniProtKB
DNA binding, bendingdefinition[GO:0008301] silver  
  • IBARefGenome
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IBARefGenome
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • IDABHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IDABHF-UCL
GO biological process 
Camera-type eye developmentdefinition[GO:0043010] silver  
  • IBARefGenome
Caudate nucleus developmentdefinition[GO:0021757]  
1
  • IMPUniProtKB
Cerebellum developmentdefinition[GO:0021549] silver  
  • IBARefGenome
Cerebral cortex developmentdefinition[GO:0021987]  
1
  • IEPBHF-UCL
Embryo developmentdefinition[GO:0009790] silver  
  • IBARefGenome
Growthdefinition[GO:0040007] silver  
  • IBARefGenome
Lung alveolus developmentdefinition[GO:0048286] silver  
  • IBARefGenome
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDABHF-UCL
Pattern specification processdefinition[GO:0007389] silver  
  • IBARefGenome
Positive regulation of epithelial cell proliferation involved in lung morphogenesisdefinition[GO:0060501] silver  
  • IBARefGenome
Positive regulation of mesenchymal cell proliferationdefinition[GO:0002053] silver  
  • IBARefGenome
Post-embryonic developmentdefinition[GO:0009791] silver  
  • IBARefGenome
Putamen developmentdefinition[GO:0021758]  
1
  • IMPUniProtKB
Righting reflexdefinition[GO:0060013] silver  
  • IBARefGenome
Skeletal muscle tissue developmentdefinition[GO:0007519] silver  
  • IBARefGenome
Smooth muscle tissue developmentdefinition[GO:0048745] silver  
  • IBARefGenome
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Vocal learningdefinition[GO:0042297] silver  
  • IBARefGenome
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FOXP2
GenomeRNAi: 93986
PRO: PR:O15409