SLC16A3 - Monocarboxylate transporter 4 - human protein (Function)
 
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Protein
Gene
References

 
SLC16A3 »  Monocarboxylate transporter 4  (MCT 4)
 
Protein also known as:  Solute carrier family 16 member 3.
Gene name:  SLC16A3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the major facilitator superfamily (mfs)  2.A.1.13.6  
GO molecular function 
Monocarboxylic acid transmembrane transporter activitydefinition[GO:0008028]  
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  • TASPINC
Poly(A) RNA bindingdefinition[GO:0044822]  
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  • IDAUniProtKB
Secondary active monocarboxylate transmembrane transporter activitydefinition[GO:0015355] silver  
  • IEAInterPro 2 GO
Symporter activitydefinition[GO:0015293]  
  • IEAUniProtKB KW
GO biological process 
Monocarboxylic acid transportdefinition[GO:0015718]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathways:
Bile salt and organic anion SLC transporters  REACT_20633  
Hemostasis  REACT_604  
Metabolism  REACT_111217  
Transmembrane transport of small molecules  REACT_15518  
Caution 
Was initially assigned as monocarboxylate transporter 3 (MCT3) (PubMed9425115). However, it was later shown that it corresponds to monocarboxylate transporter 4 (MCT4).  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLC16A3
GenomeRNAi: 9123
PRO: PR:O15427