INSIG1 - Insulin-induced gene 1 protein - human protein (Function)
 
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INSIG1 »  Insulin-induced gene 1 protein  (INSIG-1)
 
Gene name:  INSIG1
Family name: INSIG
Entry whose protein(s) existence is based on evidence at protein level
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1 37 2
GENE REF ISO

Function

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Overview 
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.  
5
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • TASPINC
Cholesterol biosynthetic processdefinition[GO:0006695] silver  
  • IEAOrtholog Compara
Cranial suture morphogenesisdefinition[GO:0060363] silver  
  • IEAOrtholog Compara
Inner ear morphogenesisdefinition[GO:0042472] silver  
  • IEAOrtholog Compara
Metabolic processdefinition[GO:0008152]  
1
  • TASPINC
Middle ear morphogenesisdefinition[GO:0042474] silver  
  • IEAOrtholog Compara
Negative regulation of cargo loading into COPII-coated vesicledefinition[GO:1901303]  
1
  • IMPUniProtKB
Negative regulation of fat cell differentiationdefinition[GO:0045599] silver  
  • IEAOrtholog Compara
Negative regulation of fatty acid biosynthetic processdefinition[GO:0045717] silver  
  • IEAOrtholog Compara
Negative regulation of steroid biosynthetic processdefinition[GO:0010894] silver  
  • IEAOrtholog Compara
Palate developmentdefinition[GO:0060021] silver  
  • IEAOrtholog Compara
SREBP signaling pathwaydefinition[GO:0032933]  
1
  • IDAUniProtKB
Triglyceride metabolic processdefinition[GO:0006641] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
Metabolism  REACT_111217  
SREBP1A/1C/2 is retained in the endoplasmic reticulum by SCAP:cholesterol:INSIG  REACT_147840  
Note 
Expressed at high levels when nuclear SREBP levels are high as a result of sterol deprivation.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Cholesterol metabolism  definition   [KW-0153]
Lipid metabolism  definition   [KW-0443]
Steroid metabolism  definition   [KW-0753]
Sterol metabolism  definition   [KW-1207]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: INSIG1
GenomeRNAi: 3638
PRO: PR:O15503