CLOCK - Circadian locomoter output cycles protein kaput - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CLOCK »  Circadian locomoter output cycles protein kaput   [ EC 2.3.1.48 ]
 
Protein also known as:  Class E basic helix-loop-helix protein 8 (bHLHe8).
Gene name:  CLOCK
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 96 1
GENE REF ISO

Function

 show evidences
Overview 
ARNTL/2-CLOCK heterodimers activate E-box element (5'-CACGTG-3') transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression (By similarity). Acetylates primarily histones H3 and H4 (By similarity). Acetylates also a non-histone substrate: ARNTL (By similarity). Plays a role in DNA damage response (DDR) signaling during the S phase.  
1
  • CuratedUniProtKB
GO molecular function 
Core promoter bindingdefinition[GO:0001047]  
  • ISSOrtholog Curator
E-box bindingdefinition[GO:0070888]  
1
  • IDABHF-UCL
Histone acetyltransferase activitydefinition[GO:0004402]  
  • IEAEC 2 GO
Protein dimerization activitydefinition[GO:0046983] silver  
  • IEAInterPro 2 GO
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • IDABHF-UCL
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activitydefinition[GO:0000982]  
  • ISSOrtholog Curator
RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001190]  
  • ISSOrtholog Curator
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
  • ISSOrtholog Curator
Signal transducer activitydefinition[GO:0004871] silver  
  • IEAInterPro 2 GO
GO biological process 
Cellular response to ionizing radiationdefinition[GO:0071479]  
1
  • IDAUniProtKB
Circadian regulation of gene expressiondefinition[GO:0032922]  
  • ISSOrtholog Curator
Circadian rhythmdefinition[GO:0007623]  
1
  • TASPINC
DNA damage checkpointdefinition[GO:0000077]  
1
  • IMPUniProtKB
Photoperiodismdefinition[GO:0009648]  
1
  • TASPINC
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IGIMGI
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • TASPINC
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • ISSOrtholog Curator
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.48: Acetyl-CoA + [histone] CoA + acetyl-[histone].  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Circadian rhythm - mammal  hsa04710+9575  
Dopaminergic synapse  hsa04728+9575  
Herpes simplex infection  hsa05168+9575  
According to Reactome, this protein belongs to the following pathway:
Circadian Clock  REACT_24941  
Note 
CLOCK-ARNTL double mutations within the PAS domains result in syngernistic desensitization to high levels of CRY on repression of CLOCK-ARNTL transcriptional activity of PER1 and disrupt circadian rhythmicity.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
DNA damage  definition   [KW-0227]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CLOCK
GenomeRNAi: 9575
PRO: PR:O15516