CFLAR - CASP8 and FADD-like apoptosis regulator - human protein (Function)
 
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CFLAR »  CASP8 and FADD-like apoptosis regulator
 
Protein also known as:  Caspase-like apoptosis regulatory protein (CLARP). Cleaved into:  CASP8 and FADD-like apoptosis regulator subunit p12; CASP8 and FADD-like apoptosis regulator subunit p43.
Gene name:  CFLAR
Family name: Peptidase C14A
Entry whose protein(s) existence is based on evidence at protein level
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1 233 15
GENE REF ISO

Function

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Overview 
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.  
1
  • CuratedUniProtKB
GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197] silver  
  • IEAInterPro 2 GO
Enzyme activator activitydefinition[GO:0008047]  
1
  • IDAUniProtKB
Protease bindingdefinition[GO:0002020]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
7
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • IMPUniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Negative regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001237]  
2
  • IMPUniProtKB
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:1902042]  
1
  • IMPBHF-UCL
Negative regulation of myoblast fusiondefinition[GO:1901740]  
  • ISSOrtholog Curator
Positive regulation of catalytic activitydefinition[GO:0043085]  
1
  • IDAGOC
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • IEPUniProtKB
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
  • ISSOrtholog Curator
Proteolysisdefinition[GO:0006508] silver  
  • IEAInterPro 2 GO
Regulation of catalytic activitydefinition[GO:0050790]  
1
  • IDAGOC
Regulation of necroptotic processdefinition[GO:0060544]  
1
  • IDAUniProtKB
Regulation of satellite cell proliferationdefinition[GO:0014842]  
  • ISSOrtholog Curator
Skeletal muscle atrophydefinition[GO:0014732]  
  • ISSOrtholog Curator
Skeletal muscle tissue developmentdefinition[GO:0007519]  
  • ISSOrtholog Curator
Skeletal muscle tissue regenerationdefinition[GO:0043403]  
  • ISSOrtholog Curator
Skeletal myofibril assemblydefinition[GO:0014866]  
  • ISSOrtholog Curator
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Apoptosis  hsa04210+8837  
Chagas disease (American trypanosomiasis)  hsa05142+8837  
According to Reactome, this protein belongs to the following pathway:
Apoptosis  REACT_578  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CFLAR
GenomeRNAi: 8837
PRO: PR:O15519