SOCS1 - Suppressor of cytokine signaling 1 - human protein (Function)
 
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Protein
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References

 
SOCS1 »  Suppressor of cytokine signaling 1  (SOCS-1)
 
Protein also known as:  STAT-induced STAT inhibitor 1 (SSI-1).
Gene name:  SOCS1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 186 1
GENE REF ISO

Function

 show evidences
Overview 
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.  
2
  • CuratedUniProtKB
GO molecular function 
Insulin-like growth factor receptor bindingdefinition[GO:0005159]  
1
  • IPIUniProtKB
Kinase inhibitor activitydefinition[GO:0019210]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
  • IPIIntAct
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
Protein kinase inhibitor activitydefinition[GO:0004860]  
1
  • TASPINC
GO biological process 
Cellular response to amino acid stimulusdefinition[GO:0071230] silver  
  • IEAOrtholog Compara
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
  • ISSOrtholog Curator
Fat cell differentiationdefinition[GO:0045444] silver  
  • IEAOrtholog Compara
JAK-STAT cascadedefinition[GO:0007259]  
1
  • TASPINC
Negative regulation of catalytic activitydefinition[GO:0043086]  
1
  • TASGOC
  • ISSOrtholog Curator
Negative regulation of insulin receptor signaling pathwaydefinition[GO:0046627]  
  • ISSOrtholog Curator
Negative regulation of JAK-STAT cascadedefinition[GO:0046426]  
1
  • NASUniProtKB
  • ISSOrtholog Curator
Negative regulation of protein kinase activitydefinition[GO:0006469]  
1
  • TASGOC
Negative regulation of tyrosine phosphorylation of Stat3 proteindefinition[GO:0042518]  
  • ISSOrtholog Curator
Protein ubiquitinationdefinition[GO:0016567]  
  • IEAUniPathway
Regulation of catalytic activitydefinition[GO:0050790]  
1
  • TASGOC
  • ISSOrtholog Curator
Regulation of growthdefinition[GO:0040008]  
  • IEAUniProtKB KW
Regulation of protein kinase activitydefinition[GO:0045859]  
1
  • TASGOC
Regulation of protein phosphorylationdefinition[GO:0001932]  
  • ISSOrtholog Curator
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Insulin signaling pathway  hsa04910+8651  
Jak-STAT signaling pathway  hsa04630+8651  
Osteoclast differentiation  hsa04380+8651  
Toxoplasmosis  hsa05145+8651  
Type II diabetes mellitus  hsa04930+8651  
Ubiquitin mediated proteolysis  hsa04120+8651  
According to Reactome, this protein belongs to the following pathways:
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Growth regulation  definition   [KW-0341]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Signal transduction inhibitor  definition   [KW-0734]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links