CYP27B1 - 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial - human protein (Function)
 
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CYP27B1 »  25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial   [ EC 1.14.13.13 ]
 
Protein also known as:  Cytochrome P450 subfamily XXVIIB polypeptide 1.
Gene name:  CYP27B1
Family name: Cytochrome P450
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 103 1
GENE REF ISO

Function

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Overview 
Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D) to 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D) plays an important role in normal bone growth, calcium metabolism, and tissue differentiation.  
  • CuratedUniProtKB
GO molecular function 
Calcidiol 1-monooxygenase activitydefinition[GO:0004498]  
4
  • IDABHF-UCL
Heme bindingdefinition[GO:0020037] silver  
  • IEAInterPro 2 GO
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
GO biological process 
Bone mineralizationdefinition[GO:0030282]  
1
  • IEPBHF-UCL
Calcitriol biosynthetic process from calcioldefinition[GO:0036378]  
4
  • IDABHF-UCL
Calcium ion homeostasisdefinition[GO:0055074]  
1
  • IMPBHF-UCL
Calcium ion transportdefinition[GO:0006816]  
  • ISSOrtholog Curator
Decidualizationdefinition[GO:0046697]  
1
  • IEPBHF-UCL
G1 to G0 transitiondefinition[GO:0070314]  
1
  • IMPBHF-UCL
Negative regulation of calcidiol 1-monooxygenase activitydefinition[GO:0010956]  
1
  • IDABHF-UCL
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • IMPBHF-UCL
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IDABHF-UCL
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Positive regulation of keratinocyte differentiationdefinition[GO:0045618]  
1
  • IMPBHF-UCL
Positive regulation of vitamin D 24-hydroxylase activitydefinition[GO:0010980]  
1
  • IDABHF-UCL
Positive regulation of vitamin D receptor signaling pathwaydefinition[GO:0070564]  
1
  • IDABHF-UCL
Regulation of bone mineralizationdefinition[GO:0030500]  
1
  • IMPBHF-UCL
Response to estrogendefinition[GO:0043627]  
1
  • IEPBHF-UCL
Response to interferon-gammadefinition[GO:0034341]  
1
  • IDABHF-UCL
Response to lipopolysaccharidedefinition[GO:0032496]  
1
  • IDABHF-UCL
Response to vitamin Ddefinition[GO:0033280]  
1
  • IDABHF-UCL
Vitamin D catabolic processdefinition[GO:0042369] silver  
  • IEAOrtholog Compara
Vitamin D metabolic processdefinition[GO:0042359]  
1
  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.14.13.13: Calcidiol + NADPH + O(2) calcitriol + NADP(+) + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
Heme group (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+1594  
Steroid biosynthesis  hsa00100+1594  
Tuberculosis  hsa05152+1594  
According to Reactome, this protein belongs to the following pathways:
Vitamin D (calciferol) metabolism  REACT_13523  
Vitamins  REACT_13450  
 

Keywords

Molecular function 
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links