KDM6A - Lysine-specific demethylase 6A - human protein (Function)
 
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KDM6A »  Lysine-specific demethylase 6A   [ EC 1.14.11.- ]
 
Protein also known as:  Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein.
Gene name:  KDM6A
Family name: UTX
Entry whose protein(s) existence is based on evidence at protein level
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1 65 1
GENE REF ISO

Function

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Overview 
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.  
2
  • CuratedUniProtKB
GO molecular function 
Dioxygenase activitydefinition[GO:0051213]  
  • IEAUniProtKB KW
Histone demethylase activity (H3-K27 specific)definition[GO:0071558] silver  
  • IEAOrtholog Compara
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978] silver  
  • IEAOrtholog Compara
GO biological process 
Canonical Wnt signaling pathwaydefinition[GO:0060070] silver  
  • IEAOrtholog Compara
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Histone H3-K27 demethylationdefinition[GO:0071557] silver  
  • IEAOrtholog Compara
Histone H3-K4 methylationdefinition[GO:0051568]  
1
  • ISSUniProtKB
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Mesodermal cell differentiationdefinition[GO:0048333] silver  
  • IEAOrtholog Compara
Neural tube closuredefinition[GO:0001843] silver  
  • IEAOrtholog Compara
Notochord morphogenesisdefinition[GO:0048570] silver  
  • IEAOrtholog Compara
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Respiratory system processdefinition[GO:0003016] silver  
  • IEAOrtholog Compara
Somite rostral/caudal axis specificationdefinition[GO:0032525] silver  
  • IEAOrtholog Compara
Enzymatic activity 
It requires the following cofactors
Ascorbate.  
1
  • CuratedUniProtKB
Fe(2+).  
1
  • CuratedUniProtKB
Note 
Escapes X chromosome inactivation.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Chromatin regulator  definition   [KW-0156]
Dioxygenase  definition   [KW-0223]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: UTX_(gene)
GenomeRNAi: 7403
PRO: PR:O15550