CLDN3 - Claudin-3 - human protein (Function)
 
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Protein
Gene
References

 
CLDN3 »  Claudin-3
 
Protein also known as:  Clostridium perfringens enterotoxin receptor 2 (CPE-R 2).
Gene name:  CLDN3
Family name: Claudin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802] silver  
  • IEAOrtholog Compara
Structural molecule activitydefinition[GO:0005198] silver  
  • IEAInterPro 2 GO
Transmembrane signaling receptor activitydefinition[GO:0004888]  
1
  • TASPINC
GO biological process 
Calcium-independent cell-cell adhesiondefinition[GO:0016338] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666]  
1
  • IEPUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • TASGOC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell adhesion molecules (CAMs)  hsa04514+1365  
Hepatitis C  hsa05160+1365  
Leukocyte transendothelial migration  hsa04670+1365  
Tight junction  hsa04530+1365  
According to Reactome, this protein belongs to the following pathway:
Cell-Cell communication  REACT_111155  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CLDN3
GenomeRNAi: 1365
PRO: PR:O15551