MEFV - Pyrin - human protein (Function)
 
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Protein
Gene
References

 
MEFV »  Pyrin
 
Protein also known as:  Marenostrin.
Gene name:  MEFV
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 165 3
GENE REF ISO

Function

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Overview 
Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization.  
2
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
1
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • NASUniProtKB
GO biological process 
Inflammatory responsedefinition[GO:0006954]  
1
  • IDAUniProtKB
Negative regulation of inflammatory responsedefinition[GO:0050728]  
1
  • IMPBHF-UCL
Negative regulation of interleukin-1 beta productiondefinition[GO:0032691]  
1
  • IMPBHF-UCL
Negative regulation of interleukin-12 productiondefinition[GO:0032695]  
1
  • IMPBHF-UCL
Negative regulation of macrophage inflammatory protein 1 alpha productiondefinition[GO:0071641]  
1
  • IMPBHF-UCL
Positive regulation of cysteine-type endopeptidase activitydefinition[GO:2001056]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
NOD-like receptor signaling pathway  hsa04621+4210  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Inflammatory response  definition   [KW-0395]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MEFV
GenomeRNAi: 4210
PRO: PR:O15553