MEFV - Pyrin - human protein (Function)
 
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Protein
Gene
References

 
MEFV »  Pyrin
 
Protein also known as:  Marenostrin.
Gene name:  MEFV
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in innate immunity and the inflammatory response. Interacts with several components of the inflammasome complex, a large oligomeric structure which recruits and activates CASP1 and ultimately induces maturation of cytokines such as IL1B. However, the exact role of MEFV in the inflammatory pathway is uncertain as contradictory effects on IL1B processing have been reported in different experimental systems. Has been shown to activate IL1B production (PubMed16037825). Has also been shown to inhibit IL1B production (PubMed16785446, PubMed17431422). Also required for PSTPIP1-induced PYCARD oligomerization and for formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Can reduce PYCARD-induced apoptosis. Recruits PSTPIP1 to pyroptosomes, and required for PSTPIP1 oligomerization.  
9
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
1
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • NASUniProtKB
GO biological process 
Inflammatory responsedefinition[GO:0006954]  
1
  • IDAUniProtKB
Negative regulation of inflammatory responsedefinition[GO:0050728]  
1
  • IMPBHF-UCL
Negative regulation of interleukin-1 beta productiondefinition[GO:0032691]  
1
  • IMPBHF-UCL
Negative regulation of interleukin-12 productiondefinition[GO:0032695]  
1
  • IMPBHF-UCL
Negative regulation of macrophage inflammatory protein 1 alpha productiondefinition[GO:0071641]  
1
  • IMPBHF-UCL
Positive regulation of cysteine-type endopeptidase activitydefinition[GO:2001056]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
NOD-like receptor signaling pathway  hsa04621+4210  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Immunity  definition   [KW-0391]
Inflammatory response  definition   [KW-0395]
Innate immunity  definition   [KW-0399]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MEFV
GenomeRNAi: 4210
PRO: PR:O15553