MEFV - Pyrin - human protein (Function)
 
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Protein
Gene
References

 
MEFV »  Pyrin
 
Protein also known as:  Marenostrin.
Gene name:  MEFV
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (PubMed16785446, PubMed17431422, PubMed26347139). However, it may also have a positive effect in the inflammatory pathway. In different experimental systems, it has been shown to activate IL1B production (PubMed16037825). It has also been shown to be required for PSTPIP1-induced PYCARD oligomerization and for formation of inflammasomes. Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (PubMed10807793, PubMed11468188, PubMed17964261, PubMed18577712, PubMed19109554, PubMed19584923).  
11
  • UniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • UniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • UniProtKB
GO biological process 
Inflammatory responsedefinition[GO:0006954]  
1
  • UniProtKB
Negative regulation of cytokine production involved in inflammatory responsedefinition[GO:1900016]  
1
  • UniProtKB
Negative regulation of inflammatory responsedefinition[GO:0050728]  
1
  • BHF-UCL
Negative regulation of interleukin-1 beta productiondefinition[GO:0032691]  
1
  • BHF-UCL
Negative regulation of interleukin-12 productiondefinition[GO:0032695]  
1
  • BHF-UCL
Negative regulation of macrophage inflammatory protein 1 alpha productiondefinition[GO:0071641]  
1
  • BHF-UCL
Negative regulation of NLRP3 inflammasome complex assemblydefinition[GO:1900226]  
1
  • UniProtKB
Positive regulation of autophagydefinition[GO:0010508]  
1
  • UniProtKB
Positive regulation of cysteine-type endopeptidase activitydefinition[GO:2001056]  
1
  • UniProtKB
Response to interferon-gammadefinition[GO:0034341]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
NOD-like receptor signaling pathway  hsa04621+4210  
According to Reactome, this protein belongs to the following pathway:
The NLRP3 inflammasome  R-HSA-844456  
Note 
Degraded along with the delivery of its substrates to autolysosomal compartments (at protein level).  
2
  • UniProtKB
 

Keywords

Biological process 
Immunity  definition   [KW-0391]
Inflammatory response  definition   [KW-0395]
Innate immunity  definition   [KW-0399]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MEFV
GenomeRNAi: 4210
PRO: PR:O15553