KCNN4 - Intermediate conductance calcium-activated potassium channel protein 4 - human protein (Function)
 
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Gene
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KCNN4 »  Intermediate conductance calcium-activated potassium channel protein 4  (SK4)
 
Protein also known as:  Putative Gardos channel.
Gene name:  KCNN4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.  
3
  • UniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.16.2  
GO molecular function 
Calcium-activated potassium channel activitydefinition[GO:0015269]  
1
  • BHF-UCL
Calmodulin bindingdefinition[GO:0005516]  
1
  • RefGenome
Intermediate conductance calcium-activated potassium channel activitydefinition[GO:0022894]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Protein phosphatase bindingdefinition[GO:0019903]  
1
  • BHF-UCL
Not  Small conductance calcium-activated potassium channel activitydefinition[GO:0016286]  
1
  • RefGenome
GO biological process 
Calcium ion transportdefinition[GO:0006816]  
1
  • BHF-UCL
Cell volume homeostasisdefinition[GO:0006884] silver  
1
  • Ortholog Compara
Defense responsedefinition[GO:0006952]  
1
  • PINC
Immune system processdefinition[GO:0002376]  
1
  • UniProtKB KW
Phospholipid translocationdefinition[GO:0045332] silver  
1
  • Ortholog Compara
Positive regulation of protein secretiondefinition[GO:0050714] silver  
1
  • Ortholog Compara
Positive regulation of T cell receptor signaling pathwaydefinition[GO:0050862]  
1
  • BHF-UCL
Potassium ion exportdefinition[GO:0071435] silver  
1
  • Ortholog Compara
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • RefGenome
Potassium ion transportdefinition[GO:0006813]  
1
  • PINC
Saliva secretiondefinition[GO:0046541] silver  
1
  • Ortholog Compara
Stabilization of membrane potentialdefinition[GO:0030322]  
1
  • BHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Protein digestion and absorption  hsa04974+3783  
Salivary secretion  hsa04970+3783  
According to Reactome, this protein belongs to the following pathway:
Ca2+ activated K+ channels  REACT_75896  
 

Keywords

Biological process 
Immunity  definition   [KW-0391]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNN4
GenomeRNAi: 3783
PRO: PR:O15554
Chemistry
GuidetoPHARMACOLOGY: 384